MPLA shows attenuated pro-inflammatory properties and diminished capacity to activate mast cells in comparison with LPS.

Schülke, S; Flaczyk, A; Vogel, L; Gaudenzio, N; Angers, I; Löschner, B; Wolfheimer, S; Spreitzer, I; Qureshi, S; Tsai, M; Galli, S; Vieths, S; Scheurer, S

Schülke, S; Flaczyk, A; Vogel, L; Gaudenzio, N; Angers, I; Löschner, B; Wolfheimer, S; Spreitzer, I; Qureshi, S; Tsai, M; Galli, S; Vieths, S; Scheurer, S.

Affiliation

Schülke S; Vice President's Research Group 1: Molecular Allergology, Paul-Ehrlich-Institut, Langen, Germany.
Flaczyk A; Vice President's Research Group 1: Molecular Allergology, Paul-Ehrlich-Institut, Langen, Germany.
Vogel L; Division of Allergology, Paul-Ehrlich-Institut, Langen, Germany.
Gaudenzio N; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Angers I; Research Institute of the McGill University Health Center, Montréal, QC, Canada.
Löschner B; Division of Microbiology, Paul-Ehrlich-Institut, Langen, Germany.
Wolfheimer S; Vice President's Research Group 1: Molecular Allergology, Paul-Ehrlich-Institut, Langen, Germany.
Spreitzer I; Division of Microbiology, Paul-Ehrlich-Institut, Langen, Germany.
Qureshi S; Research Institute of the McGill University Health Center, Montréal, QC, Canada.
Tsai M; Department of Medicine, McGill University, Montréal, QC, Canada.
Galli S; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Vieths S; Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Scheurer S; Vice President's Research Group 1: Molecular Allergology, Paul-Ehrlich-Institut, Langen, Germany.

Allergy ; 70(10): 1259-68, 2015 Oct.

Article in En | MEDLINE | ID: mdl-26081583

Subject(s)

Lipid A/analogs & derivatives; Lipopolysaccharides/immunology; Mast Cells/immunology; Mast Cells/metabolism; Adaptor Proteins, Vesicular Transport/genetics; Adaptor Proteins, Vesicular Transport/metabolism; Animals; Antigens/immunology; B-Lymphocytes/immunology; B-Lymphocytes/metabolism; Cytokines/biosynthesis; Dendritic Cells/drug effects; Dendritic Cells/immunology; Dendritic Cells/metabolism; Disease Models, Animal; Epithelial Cells/metabolism; Humans; Inflammation Mediators/metabolism; Lipid A/immunology; Lipid A/pharmacology; Lipopolysaccharides/pharmacology; Mast Cells/drug effects; Mice; Mice, Knockout; Monocytes/drug effects; Monocytes/immunology; Monocytes/metabolism; Shock, Septic/genetics; Shock, Septic/immunology; Shock, Septic/metabolism; Th2 Cells/immunology; Th2 Cells/metabolism

Key words

adjuvant; allergy; lipopolysaccharide; mast cells; monophosphoryl lipid A

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lipopolysaccharides / Lipid A / Mast Cells Limits: Animals / Humans Language: En Journal: Allergy Year: 2015 Type: Article Affiliation country: Germany

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