Mitochondria and apoptosis: emerging concepts.
F1000Prime Rep
; 7: 42, 2015.
Article
in En
| MEDLINE
| ID: mdl-26097715
ABSTRACT
As mitochondria are the powerhouses of the cell, their damage during the cell suicide process of apoptosis is essentially responsible for cellular demise in most cells. A key family of proteins, the B-cell lymphoma-2 (BCL-2) family, determines the integrity of mitochondria in the face of apoptotic insult. A comprehensive understanding of the molecular details of how apoptosis is initiated and how it culminates is essential if apoptosis is to fulfil its undoubted potential as a therapeutic target to treat diseases ranging from cancer to neurodegenerative conditions. Recent advances have provided significant insight into the control of this fundamental process while prompting a re-evaluation of what was considered dogma in the field. Emerging evidence also points to a potential overarching control network that governs not only apoptosis but other fundamental mitochondrial processes, including mitochondrial fission/fusion and quality control.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
F1000Prime Rep
Year:
2015
Type:
Article