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Cutaneous exposure to agglomerates of silica nanoparticles and allergen results in IgE-biased immune response and increased sensitivity to anaphylaxis in mice.
Hirai, Toshiro; Yoshioka, Yasuo; Takahashi, Hideki; Ichihashi, Ko-ichi; Udaka, Asako; Mori, Takahide; Nishijima, Nobuo; Yoshida, Tokuyuki; Nagano, Kazuya; Kamada, Haruhiko; Tsunoda, Shin-ichi; Takagi, Tatsuya; Ishii, Ken J; Nabeshi, Hiromi; Yoshikawa, Tomoaki; Higashisaka, Kazuma; Tsutsumi, Yasuo.
Affiliation
  • Hirai T; Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan. t-hirai@phs.osaka-u.ac.jp.
  • Yoshioka Y; Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan. y-yoshioka@biken.osaka-u.ac.jp.
  • Takahashi H; Vaccine Creation Project, BIKEN Innovative Vaccine Research Alliance Laboratories, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan. y-yoshioka@biken.osaka-u.ac.jp.
  • Ichihashi K; BIKEN Center for Innovative Vaccine Research and Development, The Research Foundation for Microbial Diseases of Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan. y-yoshioka@biken.osaka-u.ac.jp.
  • Udaka A; Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan. h-takahashi@biken.osaka-u.ac.jp.
  • Mori T; Vaccine Creation Project, BIKEN Innovative Vaccine Research Alliance Laboratories, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka, 565-0871, Japan. h-takahashi@biken.osaka-u.ac.jp.
  • Nishijima N; Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan. koichihashi@gmail.com.
  • Yoshida T; Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan. lemontarte.au@gmail.com.
  • Nagano K; Laboratory of Innovative Antibody Engineering and Design, Center for Drug Innovation and Screening, National Institute of Biomedical Innovation, 7-6-8 Saitoasagi, Ibaraki, Osaka, 567-0085, Japan. t-mori@nibio.go.jp.
  • Kamada H; Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan. nishijima-n@phs.osaka-u.ac.jp.
  • Tsunoda S; Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan. tokucox@nihs.go.jp.
  • Takagi T; Laboratory of Biopharmaceutical Research, National Institute of Biomedical Innovation, 7-6-8 Saitoasagi, Ibaraki, Osaka, 567-0085, Japan. knagano@nibio.go.jp.
  • Ishii KJ; Laboratory of Biopharmaceutical Research, National Institute of Biomedical Innovation, 7-6-8 Saitoasagi, Ibaraki, Osaka, 567-0085, Japan. kamada@nibio.go.jp.
  • Nabeshi H; The Center for Advanced Medical Engineering and Informatics, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan. kamada@nibio.go.jp.
  • Yoshikawa T; Laboratory of Biopharmaceutical Research, National Institute of Biomedical Innovation, 7-6-8 Saitoasagi, Ibaraki, Osaka, 567-0085, Japan. tsunoda@nibio.go.jp.
  • Higashisaka K; The Center for Advanced Medical Engineering and Informatics, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan. tsunoda@nibio.go.jp.
  • Tsutsumi Y; Laboratory of Environmental Pharmacometrics, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka, 565-0871, Japan. ttakagi@phs.osaka-u.ac.jp.
Part Fibre Toxicol ; 12: 16, 2015 Jun 26.
Article in En | MEDLINE | ID: mdl-26113229
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin / Immunoglobulin E / Dermatitis, Allergic Contact / Silicon Dioxide / Antigens, Dermatophagoides / Nanoparticles / Anaphylaxis Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Part Fibre Toxicol Journal subject: TOXICOLOGIA Year: 2015 Type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin / Immunoglobulin E / Dermatitis, Allergic Contact / Silicon Dioxide / Antigens, Dermatophagoides / Nanoparticles / Anaphylaxis Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals Language: En Journal: Part Fibre Toxicol Journal subject: TOXICOLOGIA Year: 2015 Type: Article Affiliation country: Japan