Contribution of oxidative stress and prostanoids in endothelial dysfunction induced by chronic fluoxetine treatment.

Simplicio, Janaina A; Resstel, Leonardo B; Tirapelli, Daniela P C; D'Orléans-Juste, Pedro; Tirapelli, Carlos R

Simplicio, Janaina A; Resstel, Leonardo B; Tirapelli, Daniela P C; D'Orléans-Juste, Pedro; Tirapelli, Carlos R.

Affiliation

Simplicio JA; Programa de Pós-Graduação em Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, São Paulo, Brazil; Departamento de Enfermagem Psiquiátrica e Ciências Humanas, Escola de Enfermagem de Ribeirão Preto, Laboratório de Farmacologia, USP, Ribeirão Preto
Resstel LB; Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, USP, Ribeirão Preto, São Paulo, Brazil.
Tirapelli DP; Departamento de Cirurgia e Anatomia, Faculdade de Medicina de Ribeirão Preto, USP, Ribeirão Preto, São Paulo, Brazil.
D'Orléans-Juste P; Département de Pharmacologie, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, Québec, Canada.
Tirapelli CR; Departamento de Enfermagem Psiquiátrica e Ciências Humanas, Escola de Enfermagem de Ribeirão Preto, Laboratório de Farmacologia, USP, Ribeirão Preto, São Paulo, Brazil. Electronic address: crtirapelli@eerp.usp.br.

Vascul Pharmacol ; 73: 124-37, 2015 Oct.

Article in En | MEDLINE | ID: mdl-26141931

Subject(s)

Aorta/drug effects; Blood Pressure/drug effects; Dinoprost/metabolism; Endothelium, Vascular/drug effects; Fluoxetine/toxicity; Oxidative Stress/drug effects; Vasoconstriction/drug effects; Acetylcholinesterase/metabolism; Animals; Aorta/metabolism; Aorta/physiopathology; Catalase/metabolism; Cyclooxygenase 1/genetics; Cyclooxygenase 1/metabolism; Dose-Response Relationship, Drug; Endothelium, Vascular/metabolism; Endothelium, Vascular/physiopathology; GPI-Linked Proteins/metabolism; Hydrogen Peroxide/metabolism; Male; Membrane Proteins/genetics; Membrane Proteins/metabolism; Nitric Oxide Synthase Type I/genetics; Nitric Oxide Synthase Type I/metabolism; Rats, Wistar; Superoxide Dismutase/metabolism; Superoxides/metabolism; Time Factors; Vasoconstrictor Agents/pharmacology

Key words

Endothelial dysfunction; Fluoxetine; Oxidative stress; Prostanoids; Vascular reactivity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aorta / Vasoconstriction / Blood Pressure / Endothelium, Vascular / Dinoprost / Fluoxetine / Oxidative Stress Limits: Animals Language: En Journal: Vascul Pharmacol Journal subject: ANGIOLOGIA / FARMACOLOGIA Year: 2015 Type: Article

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