Attenuating HIV Tat/TAR-mediated protein expression by exploring the side chain length of positively charged residues.

Wu, Cheng-Hsun; Chen, Yi-Ping; Liu, Shing-Lung; Chien, Fan-Ching; Mou, Chung-Yuan; Cheng, Richard P

Wu, Cheng-Hsun; Chen, Yi-Ping; Liu, Shing-Lung; Chien, Fan-Ching; Mou, Chung-Yuan; Cheng, Richard P.

Affiliation

Wu CH; Department of Chemistry, National Taiwan University, Taipei 10617, Taiwan. rpcheng@ntu.edu.tw.

Org Biomol Chem ; 13(45): 11096-104, 2015 Dec 07.

Article in En | MEDLINE | ID: mdl-26399751

Subject(s)

Anti-HIV Agents/pharmacology; Gene Expression Regulation, Viral/drug effects; Gene Products, tat/pharmacology; HIV Long Terminal Repeat; HIV/genetics; Peptides/pharmacology; RNA, Viral/genetics; Amino Acid Sequence; Anti-HIV Agents/chemistry; Anti-HIV Agents/pharmacokinetics; Cell Line; Gene Products, tat/chemistry; Gene Products, tat/pharmacokinetics; HIV/drug effects; HIV/metabolism; HIV Infections/drug therapy; HIV Long Terminal Repeat/drug effects; Humans; Peptides/chemistry; Peptides/pharmacokinetics; RNA, Viral/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / RNA, Viral / Gene Expression Regulation, Viral / Gene Products, tat / HIV Long Terminal Repeat / HIV / Anti-HIV Agents Limits: Humans Language: En Journal: Org Biomol Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2015 Type: Article Affiliation country: Taiwan

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