The AMPK activator R419 improves exercise capacity and skeletal muscle insulin sensitivity in obese mice.

Marcinko, Katarina; Bujak, Adam L; Lally, James S V; Ford, Rebecca J; Wong, Tammy H; Smith, Brennan K; Kemp, Bruce E; Jenkins, Yonchu; Li, Wei; Kinsella, Todd M; Hitoshi, Yasumichi; Steinberg, Gregory R

Marcinko, Katarina; Bujak, Adam L; Lally, James S V; Ford, Rebecca J; Wong, Tammy H; Smith, Brennan K; Kemp, Bruce E; Jenkins, Yonchu; Li, Wei; Kinsella, Todd M; Hitoshi, Yasumichi; Steinberg, Gregory R.

Affiliation

Marcinko K; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, 1280 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.
Bujak AL; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, 1280 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.
Lally JS; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, 1280 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.
Ford RJ; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, 1280 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.
Wong TH; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, 1280 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.
Smith BK; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, 1280 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.
Kemp BE; Protein Chemistry and Metabolism, St Vincent's Institute and Department of Medicine, University of Melbourne, 41 Victoria Parade, Fitzroy, Victoria 3065, Australia.
Jenkins Y; Rigel Pharmaceuticals Inc., 1180 Veterans Boulevard, South San Francisco, CA 94080, USA.
Li W; Rigel Pharmaceuticals Inc., 1180 Veterans Boulevard, South San Francisco, CA 94080, USA.
Kinsella TM; Rigel Pharmaceuticals Inc., 1180 Veterans Boulevard, South San Francisco, CA 94080, USA.
Hitoshi Y; Rigel Pharmaceuticals Inc., 1180 Veterans Boulevard, South San Francisco, CA 94080, USA.
Steinberg GR; Division of Endocrinology and Metabolism, Department of Medicine, McMaster University, 1280 Main St. W., Hamilton, Ontario L8N 3Z5, Canada ; Department of Biochemistry, McMaster University, 1280 Main St. W., Hamilton, Ontario L8N 3Z5, Canada.

Mol Metab ; 4(9): 643-51, 2015 Sep.

Article in En | MEDLINE | ID: mdl-26413470

Key words

2-DG, 2-deoxyglucose; ACC, acetyl-CoA carboxylase; AICAR, 5-aminoimidazole-4-carboxamide-1-ß-d-ribofuranoside; AMPK; AMPK, AMP-activated protein kinase; AMPK-MKO, skeletal muscle-specific AMPK ß1ß2 floxed Cre-; AUC, area under the curve; COX, cytochrome c oxidase; CT, computed tomography; Complex-I; Diabetes; EDL, extensor digitorum longus; Exercise-mimetic; GDR, glucose disposal rate; GIR, glucose infusion rate; GLUT4, glucose transporter 4; HFD, high-fat diet (45% kcal fat); HGO, hepatic glucose output; Mitochondrial; OXPHOS, proteins involved in oxidative phosphorylation (electron transport chain); Obesity; R419; R419, N-(1-(4-cyanobenzyl) piperidin-4-yl)-6-(4-(4-methoxybenzoyl) piperidine-1-carbonyl; TA, tibialis anterior; Tbp, TATA-binding protein; WT, wildtype

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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies / Prognostic_studies Language: En Journal: Mol Metab Year: 2015 Type: Article Affiliation country: Canada

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