N-acetylcysteine reverses diastolic dysfunction and hypertrophy in familial hypertrophic cardiomyopathy.

Wilder, Tanganyika; Ryba, David M; Wieczorek, David F; Wolska, Beata M; Solaro, R John

Wilder, Tanganyika; Ryba, David M; Wieczorek, David F; Wolska, Beata M; Solaro, R John.

Affiliation

Wilder T; Department of Physiology and Biophysics and the Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, Chicago, Illinois; Department of Biology, College of Science and Technology, Florida A & M University, Tallahassee, Florida;
Ryba DM; Department of Physiology and Biophysics and the Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, Chicago, Illinois;
Wieczorek DF; Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Wolska BM; Department of Physiology and Biophysics and the Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, Chicago, Illinois; Department of Medicine, Section of Cardiology, University of Illinois at Chicago, Chicago, Illinois; and.
Solaro RJ; Department of Physiology and Biophysics and the Center for Cardiovascular Research, College of Medicine, University of Illinois at Chicago, Chicago, Illinois; solarorj@uic.edu.

Am J Physiol Heart Circ Physiol ; 309(10): H1720-30, 2015 Nov 15.

Article in En | MEDLINE | ID: mdl-26432840

Subject(s)

Acetylcysteine/pharmacology; Cardiomyopathy, Hypertrophic, Familial/metabolism; Diastole/drug effects; Free Radical Scavengers/pharmacology; Heart Ventricles/drug effects; Myofibrils/drug effects; Animals; Calcium/metabolism; Calcium-Binding Proteins/drug effects; Calcium-Binding Proteins/metabolism; Cardiomyopathy, Hypertrophic, Familial/genetics; Cardiomyopathy, Hypertrophic, Familial/physiopathology; Carrier Proteins/drug effects; Carrier Proteins/metabolism; Disease Models, Animal; Female; Heart Ventricles/metabolism; Heart Ventricles/physiopathology; Male; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase 1/drug effects; Mitogen-Activated Protein Kinase 1/metabolism; Mitogen-Activated Protein Kinase 3/drug effects; Mitogen-Activated Protein Kinase 3/metabolism; Myofibrils/metabolism; Oxidative Stress/drug effects; Phosphorylation/drug effects; Sarcoplasmic Reticulum Calcium-Transporting ATPases/drug effects; Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism; Tropomyosin/genetics

Key words

S-glutathionylation; cardiac myosin-binding protein C; diastolic dysfunction; oxidative stress; sarcomeres

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Acetylcysteine / Free Radical Scavengers / Cardiomyopathy, Hypertrophic, Familial / Diastole / Heart Ventricles / Myofibrils Type of study: Prognostic_studies Limits: Animals Language: En Journal: Am J Physiol Heart Circ Physiol Journal subject: CARDIOLOGIA / FISIOLOGIA Year: 2015 Type: Article

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