LRP2 Acts as SHH Clearance Receptor to Protect the Retinal Margin from Mitogenic Stimuli.

Christ, Annabel; Christa, Anna; Klippert, Julia; Eule, J Corinna; Bachmann, Sebastian; Wallace, Valerie A; Hammes, Annette; Willnow, Thomas E

Christ, Annabel; Christa, Anna; Klippert, Julia; Eule, J Corinna; Bachmann, Sebastian; Wallace, Valerie A; Hammes, Annette; Willnow, Thomas E.

Affiliation

Christ A; Max-Delbrueck-Center for Molecular Medicine, 13125 Berlin, Germany. Electronic address: annabel.christ@mdc-berlin.de.
Christa A; Max-Delbrueck-Center for Molecular Medicine, 13125 Berlin, Germany.
Klippert J; Max-Delbrueck-Center for Molecular Medicine, 13125 Berlin, Germany.
Eule JC; Small Animal Clinic, Free University Berlin, 14163 Berlin, Germany.
Bachmann S; Institute for Vegetative Anatomy, Charité University Medicine Berlin, 10117 Berlin, Germany.
Wallace VA; Toronto Western Research Institute, University Health Network, Toronto, ON M5T 2S8, Canada.
Hammes A; Max-Delbrueck-Center for Molecular Medicine, 13125 Berlin, Germany.
Willnow TE; Max-Delbrueck-Center for Molecular Medicine, 13125 Berlin, Germany. Electronic address: willnow@mdc-berlin.de.

Dev Cell ; 35(1): 36-48, 2015 Oct 12.

Article in En | MEDLINE | ID: mdl-26439398

Subject(s)

Gene Expression Regulation, Developmental; Hedgehog Proteins/metabolism; Hydrophthalmos/pathology; Low Density Lipoprotein Receptor-Related Protein-2/physiology; Mitogens/pharmacology; Neurons/pathology; Retina/pathology; Animals; Cell Proliferation/drug effects; Embryo, Mammalian/cytology; Embryo, Mammalian/drug effects; Embryo, Mammalian/metabolism; Female; Humans; Hydrophthalmos/metabolism; Immunoenzyme Techniques; In Situ Hybridization; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons/drug effects; Neurons/metabolism; Retina/drug effects; Retina/embryology; Retina/metabolism; Signal Transduction/drug effects; Stem Cells/cytology; Stem Cells/drug effects; Stem Cells/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retina / Hydrophthalmos / Gene Expression Regulation, Developmental / Low Density Lipoprotein Receptor-Related Protein-2 / Hedgehog Proteins / Mitogens / Neurons Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Dev Cell Journal subject: EMBRIOLOGIA Year: 2015 Type: Article

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