Involvement of Wnt/ß-catenin signaling in the mesenchymal stem cells promote metastatic growth and chemoresistance of cholangiocarcinoma.

Wang, Weiwei; Zhong, Wei; Yuan, Jiahui; Yan, Congcong; Hu, Shaoping; Tong, Yinping; Mao, Yubin; Hu, Tianhui; Zhang, Bing; Song, Gang

Wang, Weiwei; Zhong, Wei; Yuan, Jiahui; Yan, Congcong; Hu, Shaoping; Tong, Yinping; Mao, Yubin; Hu, Tianhui; Zhang, Bing; Song, Gang.

Affiliation

Wang W; Cancer Research Center, Medical College of Xiamen University, Xiamen 361102, China.
Zhong W; Cancer Research Center, Medical College of Xiamen University, Xiamen 361102, China.
Yuan J; Cancer Research Center, Medical College of Xiamen University, Xiamen 361102, China.
Yan C; Cancer Research Center, Medical College of Xiamen University, Xiamen 361102, China.
Hu S; Cancer Research Center, Medical College of Xiamen University, Xiamen 361102, China.
Tong Y; Cancer Research Center, Medical College of Xiamen University, Xiamen 361102, China.
Mao Y; Department of Basic Medicine, Medical College of Xiamen University, Xiamen 361102, China.
Hu T; Cancer Research Center, Medical College of Xiamen University, Xiamen 361102, China.
Zhang B; Department of Basic Medicine, Medical College of Xiamen University, Xiamen 361102, China.
Song G; Cancer Research Center, Medical College of Xiamen University, Xiamen 361102, China.

Oncotarget ; 6(39): 42276-89, 2015 Dec 08.

Article in En | MEDLINE | ID: mdl-26474277

Subject(s)

Bile Duct Neoplasms/genetics; Cholangiocarcinoma/genetics; Mesenchymal Stem Cells/metabolism; Wnt Signaling Pathway/genetics; Animals; Apoptosis/drug effects; Apoptosis/genetics; Bile Duct Neoplasms/drug therapy; Bile Duct Neoplasms/metabolism; Blotting, Western; Cell Line, Tumor; Cell Proliferation/drug effects; Cell Proliferation/genetics; Cells, Cultured; Cholangiocarcinoma/drug therapy; Cholangiocarcinoma/metabolism; Culture Media, Conditioned/pharmacology; Drug Resistance, Neoplasm/drug effects; Drug Resistance, Neoplasm/genetics; Gene Expression Regulation, Neoplastic; Ginsenosides/pharmacology; Humans; Male; Mesenchymal Stem Cells/cytology; Mice, Inbred BALB C; Mice, Nude; Microscopy, Confocal; Neoplasm Metastasis; Reverse Transcriptase Polymerase Chain Reaction; Tumor Burden/drug effects; Tumor Burden/genetics; Xenograft Model Antitumor Assays

Key words

MSCs; chemoresistance; cholangiocarcinoma; metastasis; ß-catenin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bile Duct Neoplasms / Cholangiocarcinoma / Mesenchymal Stem Cells / Wnt Signaling Pathway Limits: Animals / Humans / Male Language: En Journal: Oncotarget Year: 2015 Type: Article Affiliation country: China

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