MiR-375 is Essential for Human Spinal Motor Neuron Development and May Be Involved in Motor Neuron Degeneration.

Bhinge, Akshay; Namboori, Seema C; Bithell, Angela; Soldati, Chiara; Buckley, Noel J; Stanton, Lawrence W

Bhinge, Akshay; Namboori, Seema C; Bithell, Angela; Soldati, Chiara; Buckley, Noel J; Stanton, Lawrence W.

Affiliation

Bhinge A; Stem Cell and Developmental Biology, Genome Institute of Singapore, Singapore, Singapore.
Namboori SC; Stem Cell and Developmental Biology, Genome Institute of Singapore, Singapore, Singapore.
Bithell A; Department of Neuroscience, Centre for the Cellular Basis of Behaviour, Institute of Psychiatry, King's College London, London, UK.
Soldati C; Department of Neuroscience, Centre for the Cellular Basis of Behaviour, Institute of Psychiatry, King's College London, London, UK.
Buckley NJ; Department of Psychiatry, University of Oxford, Warneford Hospital, Headington, Oxford, United Kingdom.
Stanton LW; Stem Cell and Developmental Biology, Genome Institute of Singapore, Singapore, Singapore.

Stem Cells ; 34(1): 124-34, 2016 Jan.

Article in En | MEDLINE | ID: mdl-26507573

Subject(s)

MicroRNAs/genetics; Motor Neurons/metabolism; Motor Neurons/pathology; Nerve Degeneration/pathology; Animals; Apoptosis/genetics; Base Sequence; Humans; Mice; MicroRNAs/metabolism; Molecular Sequence Data; Muscular Atrophy, Spinal/genetics; Nerve Degeneration/genetics; Neurogenesis/genetics; Signal Transduction/genetics; Tumor Suppressor Protein p53/metabolism

Key words

CCND2; Motor neuron; PAX6/REST; miR-375

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: MicroRNAs / Motor Neurons / Nerve Degeneration Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Stem Cells Year: 2016 Type: Article Affiliation country: Singapore

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