HMGB1-Driven Inflammation and Intimal Hyperplasia After Arterial Injury Involves Cell-Specific Actions Mediated by TLR4.

Cai, Jingjing; Yuan, Hong; Wang, Qingde; Yang, Huan; Al-Abed, Yousef; Hua, Zhong; Wang, Jiemei; Chen, Dandan; Wu, Jinze; Lu, Ben; Pribis, John P; Jiang, Weihong; Yang, Kan; Hackam, David J; Tracey, Kevin J; Billiar, Timothy R; Chen, Alex F

Cai, Jingjing; Yuan, Hong; Wang, Qingde; Yang, Huan; Al-Abed, Yousef; Hua, Zhong; Wang, Jiemei; Chen, Dandan; Wu, Jinze; Lu, Ben; Pribis, John P; Jiang, Weihong; Yang, Kan; Hackam, David J; Tracey, Kevin J; Billiar, Timothy R; Chen, Alex F.

Affiliation

Cai J; From the Center of Clinical Pharmacology of the Third Xiangya Hospital (J.C., H.Y., Q.W., Z.H., J. Wu), the Center of Vascular Disease and Translational Medicine (A.F.C.), Department of Cardiology of the Third Xiangya Hospital (J.C., H.Y., W.J., K.Y.), and Department of Hematology of the Third Xiang
Yuan H; From the Center of Clinical Pharmacology of the Third Xiangya Hospital (J.C., H.Y., Q.W., Z.H., J. Wu), the Center of Vascular Disease and Translational Medicine (A.F.C.), Department of Cardiology of the Third Xiangya Hospital (J.C., H.Y., W.J., K.Y.), and Department of Hematology of the Third Xiang
Wang Q; From the Center of Clinical Pharmacology of the Third Xiangya Hospital (J.C., H.Y., Q.W., Z.H., J. Wu), the Center of Vascular Disease and Translational Medicine (A.F.C.), Department of Cardiology of the Third Xiangya Hospital (J.C., H.Y., W.J., K.Y.), and Department of Hematology of the Third Xiang
Yang H; From the Center of Clinical Pharmacology of the Third Xiangya Hospital (J.C., H.Y., Q.W., Z.H., J. Wu), the Center of Vascular Disease and Translational Medicine (A.F.C.), Department of Cardiology of the Third Xiangya Hospital (J.C., H.Y., W.J., K.Y.), and Department of Hematology of the Third Xiang
Al-Abed Y; From the Center of Clinical Pharmacology of the Third Xiangya Hospital (J.C., H.Y., Q.W., Z.H., J. Wu), the Center of Vascular Disease and Translational Medicine (A.F.C.), Department of Cardiology of the Third Xiangya Hospital (J.C., H.Y., W.J., K.Y.), and Department of Hematology of the Third Xiang
Hua Z; From the Center of Clinical Pharmacology of the Third Xiangya Hospital (J.C., H.Y., Q.W., Z.H., J. Wu), the Center of Vascular Disease and Translational Medicine (A.F.C.), Department of Cardiology of the Third Xiangya Hospital (J.C., H.Y., W.J., K.Y.), and Department of Hematology of the Third Xiang
Wang J; From the Center of Clinical Pharmacology of the Third Xiangya Hospital (J.C., H.Y., Q.W., Z.H., J. Wu), the Center of Vascular Disease and Translational Medicine (A.F.C.), Department of Cardiology of the Third Xiangya Hospital (J.C., H.Y., W.J., K.Y.), and Department of Hematology of the Third Xiang
Chen D; From the Center of Clinical Pharmacology of the Third Xiangya Hospital (J.C., H.Y., Q.W., Z.H., J. Wu), the Center of Vascular Disease and Translational Medicine (A.F.C.), Department of Cardiology of the Third Xiangya Hospital (J.C., H.Y., W.J., K.Y.), and Department of Hematology of the Third Xiang
Wu J; From the Center of Clinical Pharmacology of the Third Xiangya Hospital (J.C., H.Y., Q.W., Z.H., J. Wu), the Center of Vascular Disease and Translational Medicine (A.F.C.), Department of Cardiology of the Third Xiangya Hospital (J.C., H.Y., W.J., K.Y.), and Department of Hematology of the Third Xiang
Lu B; From the Center of Clinical Pharmacology of the Third Xiangya Hospital (J.C., H.Y., Q.W., Z.H., J. Wu), the Center of Vascular Disease and Translational Medicine (A.F.C.), Department of Cardiology of the Third Xiangya Hospital (J.C., H.Y., W.J., K.Y.), and Department of Hematology of the Third Xiang
Pribis JP; From the Center of Clinical Pharmacology of the Third Xiangya Hospital (J.C., H.Y., Q.W., Z.H., J. Wu), the Center of Vascular Disease and Translational Medicine (A.F.C.), Department of Cardiology of the Third Xiangya Hospital (J.C., H.Y., W.J., K.Y.), and Department of Hematology of the Third Xiang
Jiang W; From the Center of Clinical Pharmacology of the Third Xiangya Hospital (J.C., H.Y., Q.W., Z.H., J. Wu), the Center of Vascular Disease and Translational Medicine (A.F.C.), Department of Cardiology of the Third Xiangya Hospital (J.C., H.Y., W.J., K.Y.), and Department of Hematology of the Third Xiang
Yang K; From the Center of Clinical Pharmacology of the Third Xiangya Hospital (J.C., H.Y., Q.W., Z.H., J. Wu), the Center of Vascular Disease and Translational Medicine (A.F.C.), Department of Cardiology of the Third Xiangya Hospital (J.C., H.Y., W.J., K.Y.), and Department of Hematology of the Third Xiang
Hackam DJ; From the Center of Clinical Pharmacology of the Third Xiangya Hospital (J.C., H.Y., Q.W., Z.H., J. Wu), the Center of Vascular Disease and Translational Medicine (A.F.C.), Department of Cardiology of the Third Xiangya Hospital (J.C., H.Y., W.J., K.Y.), and Department of Hematology of the Third Xiang
Tracey KJ; From the Center of Clinical Pharmacology of the Third Xiangya Hospital (J.C., H.Y., Q.W., Z.H., J. Wu), the Center of Vascular Disease and Translational Medicine (A.F.C.), Department of Cardiology of the Third Xiangya Hospital (J.C., H.Y., W.J., K.Y.), and Department of Hematology of the Third Xiang
Billiar TR; From the Center of Clinical Pharmacology of the Third Xiangya Hospital (J.C., H.Y., Q.W., Z.H., J. Wu), the Center of Vascular Disease and Translational Medicine (A.F.C.), Department of Cardiology of the Third Xiangya Hospital (J.C., H.Y., W.J., K.Y.), and Department of Hematology of the Third Xiang
Chen AF; From the Center of Clinical Pharmacology of the Third Xiangya Hospital (J.C., H.Y., Q.W., Z.H., J. Wu), the Center of Vascular Disease and Translational Medicine (A.F.C.), Department of Cardiology of the Third Xiangya Hospital (J.C., H.Y., W.J., K.Y.), and Department of Hematology of the Third Xiang

Arterioscler Thromb Vasc Biol ; 35(12): 2579-93, 2015 Dec.

Article in En | MEDLINE | ID: mdl-26515416

Subject(s)

Carotid Arteries/metabolism; Carotid Artery Injuries/metabolism; HMGB1 Protein/metabolism; Neointima; Toll-Like Receptor 4/metabolism; Vascular System Injuries/metabolism; Vasculitis/metabolism; Adaptor Proteins, Vesicular Transport/metabolism; Animals; Carotid Arteries/pathology; Carotid Artery Injuries/genetics; Carotid Artery Injuries/pathology; Cell Movement; Cell Proliferation; Cells, Cultured; Chemotaxis, Leukocyte; Cytokines/metabolism; Disease Models, Animal; HMGB1 Protein/deficiency; HMGB1 Protein/genetics; Humans; Hyperplasia; Inflammation Mediators/metabolism; Macrophages, Peritoneal/metabolism; Mice, Inbred C57BL; Mice, Knockout; Myeloid Differentiation Factor 88/genetics; Myeloid Differentiation Factor 88/metabolism; Myocytes, Smooth Muscle/metabolism; Myocytes, Smooth Muscle/pathology; Signal Transduction; Time Factors; Toll-Like Receptor 4/deficiency; Toll-Like Receptor 4/genetics; Vascular System Injuries/genetics; Vascular System Injuries/pathology; Vasculitis/genetics; Vasculitis/pathology

Key words

HMGBI protein; angioplasty; carotid artery injuries; hyperplasia; macrophages

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vasculitis / Carotid Arteries / Carotid Artery Injuries / HMGB1 Protein / Toll-Like Receptor 4 / Vascular System Injuries / Neointima Type of study: Prognostic_studies Language: En Journal: Arterioscler Thromb Vasc Biol Journal subject: ANGIOLOGIA Year: 2015 Type: Article

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