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RAS/MAPK Activation Is Associated with Reduced Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer: Therapeutic Cooperation Between MEK and PD-1/PD-L1 Immune Checkpoint Inhibitors.
Loi, Sherene; Dushyanthen, Sathana; Beavis, Paul A; Salgado, Roberto; Denkert, Carsten; Savas, Peter; Combs, Susan; Rimm, David L; Giltnane, Jennifer M; Estrada, Monica V; Sánchez, Violeta; Sanders, Melinda E; Cook, Rebecca S; Pilkinton, Mark A; Mallal, Simon A; Wang, Kai; Miller, Vincent A; Stephens, Phil J; Yelensky, Roman; Doimi, Franco D; Gómez, Henry; Ryzhov, Sergey V; Darcy, Phillip K; Arteaga, Carlos L; Balko, Justin M.
Affiliation
  • Loi S; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Australia. justin.balko@vanderbilt.edu sherene.loi@petermac.org.
  • Dushyanthen S; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
  • Beavis PA; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
  • Salgado R; Breast Cancer Translational Research Laboratory, Institute Jules Bordet, Brussels, Department of Pathology, GZA Antwerp, Belgium.
  • Denkert C; Charité University and German Cancer Consortium (DKTK), Berlin, Germany.
  • Savas P; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
  • Combs S; Departments of Pathology and Medicine, Yale University, New Haven, Connecticut.
  • Rimm DL; Departments of Pathology and Medicine, Yale University, New Haven, Connecticut.
  • Giltnane JM; Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee. Breast Cancer Program, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.
  • Estrada MV; Breast Cancer Program, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.
  • Sánchez V; Breast Cancer Program, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.
  • Sanders ME; Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee. Breast Cancer Program, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.
  • Cook RS; Breast Cancer Program, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee. Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee.
  • Pilkinton MA; Department of Medicine, Vanderbilt University, Nashville, Tennessee.
  • Mallal SA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee. Department of Medicine, Vanderbilt University, Nashville, Tennessee.
  • Wang K; Foundation Medicine, Cambridge, Massachusetts.
  • Miller VA; Foundation Medicine, Cambridge, Massachusetts.
  • Stephens PJ; Foundation Medicine, Cambridge, Massachusetts.
  • Yelensky R; Foundation Medicine, Cambridge, Massachusetts.
  • Doimi FD; Instituto Nacional de Enfermedades Neoplásicas (INEN), Lima, Perú.
  • Gómez H; Instituto Nacional de Enfermedades Neoplásicas (INEN), Lima, Perú.
  • Ryzhov SV; Maine Medical Center Research Institute, Scarborough, Maine.
  • Darcy PK; Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, Australia.
  • Arteaga CL; Breast Cancer Program, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee. Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee. Department of Medicine, Vanderbilt University, Nashville, Tennessee.
  • Balko JM; Breast Cancer Program, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee. Department of Medicine, Vanderbilt University, Nashville, Tennessee. justin.balko@vanderbilt.edu sherene.loi@petermac.org.
Clin Cancer Res ; 22(6): 1499-509, 2016 Mar 15.
Article in En | MEDLINE | ID: mdl-26515496
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lymphocytes, Tumor-Infiltrating / Ras Proteins / Mitogen-Activated Protein Kinases / Triple Negative Breast Neoplasms Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2016 Type: Article
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lymphocytes, Tumor-Infiltrating / Ras Proteins / Mitogen-Activated Protein Kinases / Triple Negative Breast Neoplasms Type of study: Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2016 Type: Article