Luteolin Inhibits Breast Cancer Development and Progression In Vitro and In Vivo by Suppressing Notch Signaling and Regulating MiRNAs.

Sun, Da-Wei; Zhang, He-Da; Mao, Ling; Mao, Chang-Fei; Chen, Wei; Cui, Meng; Ma, Rong; Cao, Hai-Xia; Jing, Chang-Weng; Wang, Zhuo; Wu, Jian-Zhong; Tang, Jin-Hai

Sun, Da-Wei; Zhang, He-Da; Mao, Ling; Mao, Chang-Fei; Chen, Wei; Cui, Meng; Ma, Rong; Cao, Hai-Xia; Jing, Chang-Weng; Wang, Zhuo; Wu, Jian-Zhong; Tang, Jin-Hai.

Cell Physiol Biochem ; 37(5): 1693-711, 2015.

Article in En | MEDLINE | ID: mdl-26545287

Subject(s)

Luteolin/pharmacology; MicroRNAs/metabolism; Receptor, Notch1/metabolism; Signal Transduction/drug effects; Animals; Antineoplastic Agents/pharmacology; Antineoplastic Agents/therapeutic use; Breast Neoplasms/drug therapy; Breast Neoplasms/metabolism; Breast Neoplasms/pathology; Cell Line, Tumor; Cell Movement/drug effects; Cell Survival/drug effects; Female; Human Umbilical Vein Endothelial Cells; Humans; Luteolin/therapeutic use; MCF-7 Cells; Matrix Metalloproteinase 2/genetics; Matrix Metalloproteinase 2/metabolism; Matrix Metalloproteinase 9/genetics; Matrix Metalloproteinase 9/metabolism; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs/antagonists & inhibitors; MicroRNAs/genetics; Neovascularization, Physiologic/drug effects; Receptor, Notch1/antagonists & inhibitors; Receptor, Notch1/genetics; S Phase Cell Cycle Checkpoints/drug effects; Transplantation, Heterologous; Vascular Endothelial Growth Factor A/genetics; Vascular Endothelial Growth Factor A/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / MicroRNAs / Luteolin / Receptor, Notch1 Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Cell Physiol Biochem Journal subject: BIOQUIMICA / FARMACOLOGIA Year: 2015 Type: Article

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