Glutathione-S-transferase omega 1 (GSTO1-1) acts as mediator of signaling pathways involved in aflatoxin B1-induced apoptosis-autophagy crosstalk in macrophages.

Paul, Souren; Jakhar, Rekha; Bhardwaj, Monika; Kang, Sun Chul

Paul, Souren; Jakhar, Rekha; Bhardwaj, Monika; Kang, Sun Chul.

Affiliation

Paul S; Department of Biotechnology, Daegu University, Kyoungsan, Kyoungbook 712-714, Republic of Korea.
Jakhar R; Department of Biotechnology, Daegu University, Kyoungsan, Kyoungbook 712-714, Republic of Korea.
Bhardwaj M; Department of Biotechnology, Daegu University, Kyoungsan, Kyoungbook 712-714, Republic of Korea.
Kang SC; Department of Biotechnology, Daegu University, Kyoungsan, Kyoungbook 712-714, Republic of Korea. Electronic address: sckang@daegu.ac.kr.

Free Radic Biol Med ; 89: 1218-30, 2015 Dec.

Article in En | MEDLINE | ID: mdl-26561775

Subject(s)

Aflatoxin B1/pharmacology; Apoptosis/drug effects; Autophagy/drug effects; Carrier Proteins/metabolism; Glutathione Transferase/metabolism; Macrophages/drug effects; Poisons/pharmacology; Signal Transduction/drug effects; Animals; Blotting, Western; Cell Proliferation; Cells, Cultured; Electrophoretic Mobility Shift Assay; Glutathione/metabolism; Immunoprecipitation; JNK Mitogen-Activated Protein Kinases/genetics; JNK Mitogen-Activated Protein Kinases/metabolism; Macrophages/metabolism; Macrophages/pathology; Mice; Oxidative Stress/drug effects; Phosphorylation/drug effects; Protein Processing, Post-Translational; RNA, Messenger/genetics; Reactive Oxygen Species/metabolism; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction

Key words

Aflatoxin; Apoptosis; Autophagy; Glutathione-S-transferase; JNK; Protein glutathionylation; Unfolded protein response

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Poisons / Autophagy / Signal Transduction / Carrier Proteins / Aflatoxin B1 / Apoptosis / Glutathione Transferase / Macrophages Type of study: Prognostic_studies Limits: Animals Language: En Journal: Free Radic Biol Med Journal subject: BIOQUIMICA / MEDICINA Year: 2015 Type: Article

Fulltext

XML

PubMed Links

Search on Google