APPL proteins promote TGFß-induced nuclear transport of the TGFß type I receptor intracellular domain.

Song, Jie; Mu, Yabing; Li, Chunyan; Bergh, Anders; Miaczynska, Marta; Heldin, Carl-Henrik; Landström, Marene

Song, Jie; Mu, Yabing; Li, Chunyan; Bergh, Anders; Miaczynska, Marta; Heldin, Carl-Henrik; Landström, Marene.

Affiliation

Song J; Medical Biosciences, Umeå University, Umeå, Sweden.
Mu Y; Medical Biosciences, Umeå University, Umeå, Sweden.
Li C; Implant Center, Stomatological Hospital, Jilin University, Changchun, China.
Bergh A; Medical Biosciences, Umeå University, Umeå, Sweden.
Miaczynska M; International Institute of Molecular and Cell Biology, Laboratory of Cell Biology, Warsaw, Poland.
Heldin CH; Ludwig Institute for Cancer Research Ltd, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Landström M; Medical Biosciences, Umeå University, Umeå, Sweden.

Oncotarget ; 7(1): 279-92, 2016 Jan 05.

Article in En | MEDLINE | ID: mdl-26583432

Subject(s)

Adaptor Proteins, Signal Transducing/metabolism; Cell Nucleus/metabolism; Protein Serine-Threonine Kinases/metabolism; Receptors, Transforming Growth Factor beta/metabolism; Transforming Growth Factor beta/pharmacology; Active Transport, Cell Nucleus/drug effects; Adaptor Proteins, Signal Transducing/genetics; Binding Sites/genetics; Breast Neoplasms/genetics; Breast Neoplasms/metabolism; Breast Neoplasms/pathology; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Immunoblotting; Male; Microscopy, Confocal; Prostatic Neoplasms/genetics; Prostatic Neoplasms/metabolism; Prostatic Neoplasms/pathology; Protein Serine-Threonine Kinases/genetics; RNA Interference; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta/genetics; Reverse Transcriptase Polymerase Chain Reaction; TNF Receptor-Associated Factor 6/genetics; TNF Receptor-Associated Factor 6/metabolism

Key words

APPL proteins; prostate cancer; signal transduction; transforming growth factor ß; tumour necrosis factor receptor-associated factor 6

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Nucleus / Transforming Growth Factor beta / Protein Serine-Threonine Kinases / Receptors, Transforming Growth Factor beta / Adaptor Proteins, Signal Transducing Type of study: Prognostic_studies Limits: Humans / Male Language: En Journal: Oncotarget Year: 2016 Type: Article Affiliation country: Sweden

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