High-Throughput Screening (HTS) by NMR Guided Identification of Novel Agents Targeting the Protein Docking Domain of YopH.

Bottini, Angel; Wu, Bainan; Barile, Elisa; De, Surya K; Leone, Marilisa; Pellecchia, Maurizio

Bottini, Angel; Wu, Bainan; Barile, Elisa; De, Surya K; Leone, Marilisa; Pellecchia, Maurizio.

Affiliation

Bottini A; Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, LaâJolla, CA, 92037, USA.
Wu B; Sanford Burnham Prebys Graduate School of Biomedical Sciences, 10901 North Torrey Pines Road, LaâJolla, CA, 92037, USA.
Barile E; Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, LaâJolla, CA, 92037, USA.
De SK; Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, LaâJolla, CA, 92037, USA.
Leone M; Division of Biomedical Sciences, School of Medicine, University of California Riverside, 900 University Avenue, Riverside, CA, 92521, USA.
Pellecchia M; Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, LaâJolla, CA, 92037, USA.

ChemMedChem ; 11(8): 919-27, 2016 Apr 19.

Article in En | MEDLINE | ID: mdl-26592695

Subject(s)

Anti-Bacterial Agents/pharmacology; Bacterial Outer Membrane Proteins/chemistry; Bacterial Outer Membrane Proteins/metabolism; High-Throughput Screening Assays; Peptoids/pharmacology; Protein Tyrosine Phosphatases/chemistry; Protein Tyrosine Phosphatases/metabolism; Anti-Bacterial Agents/chemical synthesis; Anti-Bacterial Agents/chemistry; Dose-Response Relationship, Drug; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Nuclear Magnetic Resonance, Biomolecular; Peptoids/chemical synthesis; Peptoids/chemistry; Plague/drug therapy; Protein Binding/drug effects; Protein Domains/drug effects; Structure-Activity Relationship; Yersinia pestis/drug effects

Key words

NMR spectroscopy; YopH; combinatorial libraries; high-throughput screening (HTS); peptides; protein-protein interactions

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Outer Membrane Proteins / Protein Tyrosine Phosphatases / Peptoids / High-Throughput Screening Assays / Anti-Bacterial Agents Type of study: Diagnostic_studies / Screening_studies Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2016 Type: Article Affiliation country: United States

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