Can dicoumarol be used as a gonad-safe anticancer agent: an in vitro and in vivo experimental study.

Aras, Duru; Cinar, Ozgur; Cakar, Zeynep; Ozkavukcu, Sinan; Can, Alp

Aras, Duru; Cinar, Ozgur; Cakar, Zeynep; Ozkavukcu, Sinan; Can, Alp.

Affiliation

Aras D; Ankara University Biotechnology Institute, Tandogan, Ankara 06500, Turkey.
Cinar O; Department of Histology and Embryology, Laboratory for Stem Cells and Reproductive Biology, Ankara University School of Medicine, Sihhiye, Ankara 06100, Turkey.
Cakar Z; Department of Histology and Embryology, Laboratory for Stem Cells and Reproductive Biology, Ankara University School of Medicine, Sihhiye, Ankara 06100, Turkey.
Ozkavukcu S; Department of Obstetric and Gynaecology, Centre for Assisted Reproduction, Ankara University School of Medicine, Cebeci, Ankara 06590, Turkey.
Can A; Department of Histology and Embryology, Laboratory for Stem Cells and Reproductive Biology, Ankara University School of Medicine, Sihhiye, Ankara 06100, Turkey alpcan@medicine.ankara.edu.tr.

Mol Hum Reprod ; 22(1): 57-67, 2016 Jan.

Article in En | MEDLINE | ID: mdl-26612783

Subject(s)

Antineoplastic Agents/pharmacology; Dicumarol/pharmacology; Animals; Antineoplastic Agents/administration & dosage; Antineoplastic Agents/toxicity; Apoptosis/drug effects; Chlorocebus aethiops; Dicumarol/administration & dosage; Dicumarol/toxicity; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Granulosa Cells/drug effects; Humans; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mitotic Index; NAD(P)H Dehydrogenase (Quinone)/biosynthesis; NAD(P)H Dehydrogenase (Quinone)/genetics; NAD(P)H Dehydrogenase (Quinone)/physiology; Oocytes/drug effects; Organ Sparing Treatments; Ovary/drug effects; Spindle Apparatus/drug effects; Spindle Apparatus/ultrastructure; Vero Cells

Key words

apoptosis; dicoumarol; fertility preservation; meiosis; oocyte

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dicumarol / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Mol Hum Reprod Journal subject: BIOLOGIA MOLECULAR / MEDICINA REPRODUTIVA Year: 2016 Type: Article Affiliation country: Turkey

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