2-Amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine is an anti-inflammatory TLR-2, -4 and -5 response mediator in human monocytes.

Wang, Huizhi; Graves, Mark W; Zhou, Huaxin; Gu, Zhen; Lamont, Richard J; Scott, David A

Wang, Huizhi; Graves, Mark W; Zhou, Huaxin; Gu, Zhen; Lamont, Richard J; Scott, David A.

Affiliation

Wang H; Department of Oral Immunology and Infectious Diseases, University of Louisville, 501 South Preston Street, Louisville, KY, 40292, USA. huizhi.wang@louisville.edu.
Graves MW; Department of Oral Immunology and Infectious Diseases, University of Louisville, 501 South Preston Street, Louisville, KY, 40292, USA. mark.graves@louisville.edu.
Zhou H; Department of Oral Immunology and Infectious Diseases, University of Louisville, 501 South Preston Street, Louisville, KY, 40292, USA. h0zhou03@louisville.edu.
Gu Z; Department of Oral Immunology and Infectious Diseases, University of Louisville, 501 South Preston Street, Louisville, KY, 40292, USA. zhen.gu@louisville.edu.
Lamont RJ; Department of Oral Immunology and Infectious Diseases, University of Louisville, 501 South Preston Street, Louisville, KY, 40292, USA. rich.lamont@louisville.edu.
Scott DA; Department of Oral Immunology and Infectious Diseases, University of Louisville, 501 South Preston Street, Louisville, KY, 40292, USA. dascot07@louisville.edu.

Inflamm Res ; 65(1): 61-9, 2016 Jan.

Article in En | MEDLINE | ID: mdl-26613980

Subject(s)

Anti-Inflammatory Agents/pharmacology; Benzodioxoles/pharmacology; Monocytes/drug effects; Monocytes/metabolism; Pyrimidines/pharmacology; Toll-Like Receptor 2/metabolism; Toll-Like Receptor 4/metabolism; Toll-Like Receptor 5/metabolism; Cytokines/metabolism; Glycogen Synthase Kinase 3/biosynthesis; Glycogen Synthase Kinase 3/genetics; Glycogen Synthase Kinase 3 beta; Humans; Lipopolysaccharides/pharmacology; Primary Cell Culture; Receptors, Wnt/drug effects; Signal Transduction/drug effects; Toll-Like Receptor 2/drug effects; Toll-Like Receptor 4/drug effects; Toll-Like Receptor 5/drug effects

Key words

2-amino-4-(3,4-(methylenedioxy)benzylamino)-6-(3-methoxyphenyl)pyrimidine; Cytokines; GSK3ß; Inflammation; TLR; Wnt; ß-catenin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Monocytes / Benzodioxoles / Toll-Like Receptor 2 / Toll-Like Receptor 4 / Toll-Like Receptor 5 / Anti-Inflammatory Agents Limits: Humans Language: En Journal: Inflamm Res Journal subject: ALERGIA E IMUNOLOGIA / PATOLOGIA Year: 2016 Type: Article Affiliation country: United States

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