Endothelial LRP1 transports amyloid-ß(1-42) across the blood-brain barrier.

Storck, Steffen E; Meister, Sabrina; Nahrath, Julius; Meißner, Julius N; Schubert, Nils; Di Spiezio, Alessandro; Baches, Sandra; Vandenbroucke, Roosmarijn E; Bouter, Yvonne; Prikulis, Ingrid; Korth, Carsten; Weggen, Sascha; Heimann, Axel; Schwaninger, Markus; Bayer, Thomas A; Pietrzik, Claus U

Storck, Steffen E; Meister, Sabrina; Nahrath, Julius; Meißner, Julius N; Schubert, Nils; Di Spiezio, Alessandro; Baches, Sandra; Vandenbroucke, Roosmarijn E; Bouter, Yvonne; Prikulis, Ingrid; Korth, Carsten; Weggen, Sascha; Heimann, Axel; Schwaninger, Markus; Bayer, Thomas A; Pietrzik, Claus U.

J Clin Invest ; 126(1): 123-36, 2016 Jan.

Article in En | MEDLINE | ID: mdl-26619118

Subject(s)

Amyloid beta-Peptides/pharmacokinetics; Blood-Brain Barrier; Endothelial Cells/physiology; Peptide Fragments/pharmacokinetics; Receptors, LDL/physiology; Tumor Suppressor Proteins/physiology; Animals; Brain/metabolism; Cognition Disorders/etiology; Low Density Lipoprotein Receptor-Related Protein-1; Mice; Mice, Inbred C57BL; Protein Transport; Transcytosis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Receptors, LDL / Blood-Brain Barrier / Amyloid beta-Peptides / Tumor Suppressor Proteins / Endothelial Cells Type of study: Etiology_studies Limits: Animals Language: En Journal: J Clin Invest Year: 2016 Type: Article

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