Defective sirtuin-1 increases IL-4 expression through acetylation of GATA-3 in patients with severe asthma.

Colley, Thomas; Mercado, Nicolas; Kunori, Yuichi; Brightling, Christopher; Bhavsar, Pankaj K; Barnes, Peter J; Ito, Kazuhiro

Colley, Thomas; Mercado, Nicolas; Kunori, Yuichi; Brightling, Christopher; Bhavsar, Pankaj K; Barnes, Peter J; Ito, Kazuhiro.

Affiliation

Colley T; Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Mercado N; Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Kunori Y; Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Brightling C; Respiratory Medicine, Glenfield Hospital, University of Leicester, Leicester, United Kingdom.
Bhavsar PK; Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Barnes PJ; Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Ito K; Airway Disease Section, National Heart and Lung Institute, Imperial College London, London, United Kingdom. Electronic address: k.ito@imperial.ac.uk.

J Allergy Clin Immunol ; 137(5): 1595-1597.e7, 2016 05.

Article in En | MEDLINE | ID: mdl-26627546

Subject(s)

Asthma/immunology; GATA3 Transcription Factor/blood; Interleukin-4/blood; Sirtuin 1/blood; Acetylation; Adult; Asthma/blood; Asthma/diagnosis; Biomarkers/blood; Case-Control Studies; Female; Humans; Male; Severity of Illness Index

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Asthma / Interleukin-4 / GATA3 Transcription Factor / Sirtuin 1 Type of study: Diagnostic_studies / Observational_studies Limits: Adult / Female / Humans / Male Language: En Journal: J Allergy Clin Immunol Year: 2016 Type: Article Affiliation country: United kingdom

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