Knockdown of NogoA prevents MPP+­induced neurotoxicity in PC12 cells via the mTOR/STAT3 signaling pathway.

Zhong, Jianbin; Li, Xie; Wan, Limei; Chen, Zhibang; Zhong, Simin; Xiao, Songhua; Yan, Zhengwen

Knockdown of NogoA prevents MPP+induced neurotoxicity in PC12 cells via the mTOR/STAT3 signaling pathway.

Zhong, Jianbin; Li, Xie; Wan, Limei; Chen, Zhibang; Zhong, Simin; Xiao, Songhua; Yan, Zhengwen.

Affiliation

Zhong J; Department of Neurology, Zeng Cheng People's Hospital and Boji Hospital of Sun Yatsen University, Guangzhou, Guangdong 511300, P.R. China.
Li X; Department of Neurology, Zeng Cheng People's Hospital and Boji Hospital of Sun Yatsen University, Guangzhou, Guangdong 511300, P.R. China.
Wan L; Department of Neurology, Zeng Cheng People's Hospital and Boji Hospital of Sun Yatsen University, Guangzhou, Guangdong 511300, P.R. China.
Chen Z; Department of Neurology, Zeng Cheng People's Hospital and Boji Hospital of Sun Yatsen University, Guangzhou, Guangdong 511300, P.R. China.
Zhong S; Department of Neurology, Zeng Cheng People's Hospital and Boji Hospital of Sun Yatsen University, Guangzhou, Guangdong 511300, P.R. China.
Xiao S; Department of Neurology, Sun Yatsen Memorial Hospital of Sun Yatsen University, Guangzhou, Guangdong 511300, P.R. China.
Yan Z; Department of Neurology, Sun Yatsen Memorial Hospital of Sun Yatsen University, Guangzhou, Guangdong 511300, P.R. China.

Mol Med Rep ; 13(2): 1427-33, 2016 Feb.

Article in En | MEDLINE | ID: mdl-26648565

Subject(s)

1-Methyl-4-phenylpyridinium/toxicity; Gene Knockdown Techniques; Myelin Proteins/metabolism; Neurotoxins/toxicity; STAT3 Transcription Factor/metabolism; Signal Transduction/drug effects; TOR Serine-Threonine Kinases/metabolism; Animals; Apoptosis Regulatory Proteins/metabolism; Autophagy/drug effects; Beclin-1; Cell Survival; GPI-Linked Proteins/metabolism; Gene Silencing/drug effects; Nogo Proteins; Nogo Receptor 1; PC12 Cells; Rats; Receptors, Cell Surface/metabolism; Sirolimus/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / 1-Methyl-4-phenylpyridinium / STAT3 Transcription Factor / Gene Knockdown Techniques / TOR Serine-Threonine Kinases / Myelin Proteins / Neurotoxins Type of study: Prognostic_studies Limits: Animals Language: En Journal: Mol Med Rep Year: 2016 Type: Article

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