Serum properdin consumption as a biomarker of C5 convertase dysregulation in C3 glomerulopathy.

Corvillo, F; Bravo García-Morato, M; Nozal, P; Garrido, S; Tortajada, A; Rodríguez de Córdoba, S; López-Trascasa, M

Corvillo, F; Bravo García-Morato, M; Nozal, P; Garrido, S; Tortajada, A; Rodríguez de Córdoba, S; López-Trascasa, M.

Affiliation

Corvillo F; Unidad de Inmunología, IdiPAZ, Hospital Universitario La Paz, Madrid, Spain.
Bravo García-Morato M; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER U754), Madrid, Spain.
Nozal P; Unidad de Inmunología, IdiPAZ, Hospital Universitario La Paz, Madrid, Spain.
Garrido S; Unidad de Inmunología, IdiPAZ, Hospital Universitario La Paz, Madrid, Spain.
Tortajada A; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER U754), Madrid, Spain.
Rodríguez de Córdoba S; Unidad de Inmunología, IdiPAZ, Hospital Universitario La Paz, Madrid, Spain.
López-Trascasa M; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER U754), Madrid, Spain.

Clin Exp Immunol ; 184(1): 118-25, 2016 Apr.

Article in En | MEDLINE | ID: mdl-26660535

Subject(s)

Complement C3-C5 Convertases/immunology; Complement Pathway, Alternative; Glomerulonephritis/immunology; Properdin/immunology; Proteinuria/immunology; Adolescent; Adult; Biomarkers/blood; Child; Complement C3/genetics; Complement C3/immunology; Complement C3 Nephritic Factor/genetics; Complement C3 Nephritic Factor/immunology; Complement C3-C5 Convertases/genetics; Complement C5/genetics; Complement C5/immunology; Complement Factor B/genetics; Complement Factor B/immunology; Complement Inactivating Agents/blood; Complement Membrane Attack Complex/genetics; Complement Membrane Attack Complex/immunology; Female; Gene Expression Regulation; Glomerulonephritis/blood; Glomerulonephritis/genetics; Glomerulonephritis/pathology; Humans; Male; Middle Aged; Properdin/genetics; Proteinuria/blood; Proteinuria/genetics; Proteinuria/pathology; Retrospective Studies; Severity of Illness Index; Signal Transduction

Key words

C3 glomerulonephritis; C3 glomerulopathy; C3 nephritic factor; complement; properdin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proteinuria / Properdin / Complement Pathway, Alternative / Complement C3-C5 Convertases / Glomerulonephritis Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies Language: En Journal: Clin Exp Immunol Year: 2016 Type: Article Affiliation country: Spain

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