Chemical and Drug Induced Liver Injury/metabolism; Drug Evaluation, Preclinical; Drugs, Investigational/adverse effects; Liver/drug effects; Microsomes, Liver/drug effects; Models, Biological; Activation, Metabolic; Animals; Cell Culture Techniques/trends; Cell Line; Cells, Cultured; Chemical and Drug Induced Liver Injury/epidemiology; Chemical and Drug Induced Liver Injury/pathology; Coculture Techniques/trends; Drug Evaluation, Preclinical/trends; Drugs, Investigational/chemistry; Drugs, Investigational/pharmacokinetics; Humans; In Vitro Techniques/trends; Liver/cytology; Liver/metabolism; Liver/pathology; Microfluidics/methods; Microfluidics/trends; Microsomes, Liver/enzymology; Microsomes, Liver/metabolism; Pluripotent Stem Cells/cytology; Pluripotent Stem Cells/drug effects; Pluripotent Stem Cells/metabolism; Pluripotent Stem Cells/pathology; Recombinant Proteins/metabolism; Risk Assessment; Risk Factors; Tissue Scaffolds/trends

DILI; bioactivation; covalent binding; engineered cells; hepatocytes; hepatotoxicity; iPSCs; idiosyncrasy; microsomes; reactive metabolites