Suppression of phospho-p85&#945;-GTP-Rac1 lipid raft interaction by bichalcone analog attenuates cancer cell invasion.

Lu, Hui-Li; Chen, Shih-Shun; Hsu, Wen-Tung; Lu, Yao-Cheng; Lee, Chuan-Chun; Wu, Tian-Shung; Lin, Meng-Liang

Suppression of phospho-p85α-GTP-Rac1 lipid raft interaction by bichalcone analog attenuates cancer cell invasion.

Lu, Hui-Li; Chen, Shih-Shun; Hsu, Wen-Tung; Lu, Yao-Cheng; Lee, Chuan-Chun; Wu, Tian-Shung; Lin, Meng-Liang.

Affiliation

Lu HL; Division of Laboratory, Armed Force Taichung General Hospital, Taichung, Taiwan.
Chen SS; Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan.
Hsu WT; Division of Laboratory, Armed Force Taichung General Hospital, Taichung, Taiwan.
Lu YC; Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan.
Lee CC; Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan.
Wu TS; Department of Chemistry, National Cheng Kung University, Tainan, Taiwan.
Lin ML; Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan.

Mol Carcinog ; 55(12): 2106-2120, 2016 12.

Article in En | MEDLINE | ID: mdl-26756739

Subject(s)

Antineoplastic Agents/pharmacology; Chalcones/pharmacology; Class Ia Phosphatidylinositol 3-Kinase/metabolism; Membrane Microdomains/metabolism; Neoplasm Invasiveness/prevention & control; Piperazines/pharmacology; rac1 GTP-Binding Protein/metabolism; Cell Line, Tumor; Cell Movement/drug effects; Down-Regulation; Guanosine Triphosphate/metabolism; Humans; Matrix Metalloproteinase 2/genetics; NF-kappa B/metabolism; Neoplasm Invasiveness/genetics; Signal Transduction/drug effects

Key words

MMP-2; Rac1; bichalcone analog TSWU-CD4; invasion; p85α

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Rac1 GTP-Binding Protein / Membrane Microdomains / Chalcones / Class Ia Phosphatidylinositol 3-Kinase / Neoplasm Invasiveness / Antineoplastic Agents Limits: Humans Language: En Journal: Mol Carcinog Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2016 Type: Article Affiliation country: Taiwan

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