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Discovery of 5-aryl-1,3-dihydro-2H-imidazo[4,5-b]pyridin-2-ones as positive allosteric modulators of metabotropic glutamate subtype-2 (mGlu2) receptors with efficacy in a preclinical model of psychosis.
Layton, Mark E; Reif, Alexander J; Hartingh, Timothy J; Rodzinak, Kevin; Dudkin, Vadim; Wang, Cheng; Arrington, Ken; Kelly, Michael J; Garbaccio, Robert M; O'Brien, Julie A; Magliaro, Brian C; Uslaner, Jason M; Huszar, Sarah L; Fillgrove, Kerry L; Tang, Cuyue; Kuo, Yuhsin; Jacobson, Marlene A.
Affiliation
  • Layton ME; Department of Medicinal Chemistry, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • Reif AJ; Department of Medicinal Chemistry, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • Hartingh TJ; Department of Medicinal Chemistry, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • Rodzinak K; Department of Medicinal Chemistry, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • Dudkin V; Department of Medicinal Chemistry, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • Wang C; Department of Medicinal Chemistry, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • Arrington K; Department of Medicinal Chemistry, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • Kelly MJ; Department of Medicinal Chemistry, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • Garbaccio RM; Department of Medicinal Chemistry, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • O'Brien JA; Department of In Vitro Sciences, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • Magliaro BC; Department of Psychiatry Research, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • Uslaner JM; Department of Central Pharmacology, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • Huszar SL; Department of Central Pharmacology, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • Fillgrove KL; Department of Drug Metabolism, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • Tang C; Department of Drug Metabolism, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • Kuo Y; Department of Drug Metabolism, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States.
  • Jacobson MA; Department of Psychiatry Research, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, PA 19486, United States.
Bioorg Med Chem Lett ; 26(4): 1260-4, 2016 Feb 15.
Article in En | MEDLINE | ID: mdl-26810316
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Pyridones / Receptors, Metabotropic Glutamate / Imidazoles Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2016 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Pyridones / Receptors, Metabotropic Glutamate / Imidazoles Limits: Animals Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2016 Type: Article Affiliation country: United States