[Impact of male reproductive tract infection on semen quality].
Zhonghua Nan Ke Xue
; 21(12): 1082-6, 2015 Dec.
Article
in Zh
| MEDLINE
| ID: mdl-26817299
ABSTRACT
OBJECTIVE:
To investigate the association of male reproductive tract infection (RTI) with semen parameters and sperm DNA damage.METHODS:
We classified 1 084 males attending the infertility clinic into an RTI group (n = 300) and a non-RTI control group (n = 784). According to the WHO standards, we obtained routine semen parameters, detected sperm morphology, and determined the sperm DNA fragmentation index (DFI) by sperm chromatin structure assay.RESULTS:
There were statistically significant differences between the RTI and control groups in the semen volume ( [2.58 ± 1.20] vs [3.00 ± 2.10] ml), grade a + b sperm ([50.6 ± 17.2] vs [53.2 ± 15.8]%), grade d sperm ( [39. 8 ± 17.8] vs [36.5 ± 16.2]%), and total sperm count ([218.5 ± 185.0 ] vs [278.5 ± 375.5 ] x 10(6)/ejaculate) (all P < 0.05), but not in the males' age, sperm concentration or pH value (P > 0.05). The percentage of morphologically normal sperm was significantly lower ([3.46 ± 2.90] vs [4.61 ± 3.60%, P < 0.05) but the DFI was markedly higher in the RTI group than in the control ([19.4 ± 11.4] vs [15.2 ± 8.8]% , P < 0.01). The percentage of the cases with DFI > 30% was remarkably higher (13.0 vs 5.74% ) while that of the cases with DFI < 10% dramatically lower in the former than in the latter (16.0 vs 28.0%). The level of seminal plasma elastase was correlated negatively to sperm concentration, sperm count, and the percentage of morphologically normal sperm (P < 0.05) but positively to DFI and grade d sperm (P < 0.05 or P < 0.01).CONCLUSION:
Male reproductive tract infection not only affects semen parameters and sperm morphology but also causes serious sperm DNA damage.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Semen Analysis
/
Reproductive Tract Infections
/
Infertility, Male
Type of study:
Guideline
Limits:
Humans
/
Male
Language:
Zh
Journal:
Zhonghua Nan Ke Xue
Journal subject:
MEDICINA REPRODUTIVA
Year:
2015
Type:
Article