Gastrointestinal transit of Sinemet CR in healthy volunteers.
Neurology
; 39(11 Suppl 2): 53-8, 1989 Nov.
Article
in En
| MEDLINE
| ID: mdl-2685651
ABSTRACT
The gastrointestinal transit and systemic absorption of Sinemet CR (50/200) and standard Sinemet (25/100) have been studied in fasting and "fed" healthy human subjects. Both formulations were labeled with a gamma-emitting radionuclide, and their gastric emptying, colon arrival, and in vivo dissolution profiles were monitored using gamma scintigraphy. The standard dosage forms were found to disperse soon after administration and to empty rapidly from both the fasting and the "fed" stomach. The erosion of the controlled-release (CR) system was independent of food. Dosing after a light breakfast altered the gastric emptying profile of the CR formulation and led to significant differences in the plasma levels of levodopa.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gastrointestinal Transit
/
Carbidopa
/
Levodopa
/
Antiparkinson Agents
Type of study:
Clinical_trials
Limits:
Humans
/
Male
Language:
En
Journal:
Neurology
Year:
1989
Type:
Article
Affiliation country:
United kingdom