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Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo.
Simonetti, Francesco R; Sobolewski, Michele D; Fyne, Elizabeth; Shao, Wei; Spindler, Jonathan; Hattori, Junko; Anderson, Elizabeth M; Watters, Sarah A; Hill, Shawn; Wu, Xiaolin; Wells, David; Su, Li; Luke, Brian T; Halvas, Elias K; Besson, Guillaume; Penrose, Kerri J; Yang, Zhiming; Kwan, Richard W; Van Waes, Carter; Uldrick, Thomas; Citrin, Deborah E; Kovacs, Joseph; Polis, Michael A; Rehm, Catherine A; Gorelick, Robert; Piatak, Michael; Keele, Brandon F; Kearney, Mary F; Coffin, John M; Hughes, Stephen H; Mellors, John W; Maldarelli, Frank.
Affiliation
  • Simonetti FR; HIV Dynamics and Replication Program, National Cancer Institute, Frederick, MD 21702; Department of Biomedical and Clinical Sciences L. Sacco, University of Milan, 20157 Milan, Italy;
  • Sobolewski MD; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261;
  • Fyne E; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261;
  • Shao W; Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702;
  • Spindler J; HIV Dynamics and Replication Program, National Cancer Institute, Frederick, MD 21702;
  • Hattori J; HIV Dynamics and Replication Program, National Cancer Institute, Frederick, MD 21702;
  • Anderson EM; HIV Dynamics and Replication Program, National Cancer Institute, Frederick, MD 21702;
  • Watters SA; HIV Dynamics and Replication Program, National Cancer Institute, Frederick, MD 21702;
  • Hill S; HIV Dynamics and Replication Program, National Cancer Institute, Frederick, MD 21702;
  • Wu X; Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702;
  • Wells D; Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702;
  • Su L; Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702;
  • Luke BT; Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702;
  • Halvas EK; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261;
  • Besson G; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261;
  • Penrose KJ; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261;
  • Yang Z; Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892;
  • Kwan RW; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;
  • Van Waes C; National Institute on Deafness and Communication Disorders Head and Neck Surgery Branch, National Institute on Deafness and Communication Disorders, National Institutes of Health, Bethesda, MD 20892; Radiation Oncology Branch, National Cancer Institute, Bethesda, MD 20892;
  • Uldrick T; HIV and AIDS Malignancy Branch, National Cancer Institute, Bethesda, MD 20892;
  • Citrin DE; Radiation Oncology Branch, National Cancer Institute, Bethesda, MD 20892;
  • Kovacs J; Critical Care Medicine Department, National Institutes of Health Clinical Center, National Institutes of Health, Bethesda, MD 20892;
  • Polis MA; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;
  • Rehm CA; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892;
  • Gorelick R; AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory, Frederick, MD 21702;
  • Piatak M; AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory, Frederick, MD 21702;
  • Keele BF; AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory, Frederick, MD 21702;
  • Kearney MF; HIV Dynamics and Replication Program, National Cancer Institute, Frederick, MD 21702;
  • Coffin JM; Department of Molecular Biology and Microbiology, Tufts University, Boston, MA 02111 john.coffin@tufts.edu fmalli@mail.nih.gov.
  • Hughes SH; HIV Dynamics and Replication Program, National Cancer Institute, Frederick, MD 21702;
  • Mellors JW; Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261;
  • Maldarelli F; HIV Dynamics and Replication Program, National Cancer Institute, Frederick, MD 21702; john.coffin@tufts.edu fmalli@mail.nih.gov.
Proc Natl Acad Sci U S A ; 113(7): 1883-8, 2016 Feb 16.
Article in En | MEDLINE | ID: mdl-26858442
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Virus Replication / CD4-Positive T-Lymphocytes / HIV-1 Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2016 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Virus Replication / CD4-Positive T-Lymphocytes / HIV-1 Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2016 Type: Article