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Quaternary Lidocaine Derivative QX-314 Activates and Permeates Human TRPV1 and TRPA1 to Produce Inhibition of Sodium Channels and Cytotoxicity.
Stueber, Thomas; Eberhardt, Mirjam J; Hadamitzky, Christoph; Jangra, Annette; Schenk, Stefan; Dick, Felicia; Stoetzer, Carsten; Kistner, Katrin; Reeh, Peter W; Binshtok, Alexander M; Leffler, Andreas.
Affiliation
  • Stueber T; From the Department of Anaesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany (T.S., M.J.E., C.H., A.J., S.S., F.D., C.S., A.L.); Department of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany (K.K., P.W.R.); and Department of Medical Neurobiology, Institute for Medical Research Israel-Canada, The Hebrew University Faculty of Medicine, and The Edmond and Lily Safra Center for Brain Sciences, The Hebrew Universit
Anesthesiology ; 124(5): 1153-65, 2016 May.
Article in En | MEDLINE | ID: mdl-26859646
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Calcium Channels / Cell Survival / Sodium Channel Blockers / Transient Receptor Potential Channels / TRPV Cation Channels / Anesthetics, Local / Lidocaine / Nerve Tissue Proteins Limits: Humans Language: En Journal: Anesthesiology Year: 2016 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Calcium Channels / Cell Survival / Sodium Channel Blockers / Transient Receptor Potential Channels / TRPV Cation Channels / Anesthetics, Local / Lidocaine / Nerve Tissue Proteins Limits: Humans Language: En Journal: Anesthesiology Year: 2016 Type: Article