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The value of integrating pre-clinical data to predict nausea and vomiting risk in humans as illustrated by AZD3514, a novel androgen receptor modulator.
Grant, Claire; Ewart, Lorna; Muthas, Daniel; Deavall, Damian; Smith, Simon A; Clack, Glen; Newham, Pete.
Affiliation
  • Grant C; Drug Safety and Metabolism, AstraZeneca, Alderley Park, Macclesfield SK10 4TG, United Kingdom. Electronic address: claire.grant@astrazeneca.com.
  • Ewart L; Drug Safety and Metabolism, AstraZeneca, Da Vinci Building, Melbourn Science Park, Cambridge Road, Melbourn, Royston SG8 6HB, United Kingdom.
  • Muthas D; Respiratory, Inflammation and Autoimmunity iMED, AstraZeneca, Pepparedsleden 1, 431 83 Mölndal, Sweden.
  • Deavall D; Drug Safety and Metabolism, AstraZeneca, Alderley Park, Macclesfield SK10 4TG, United Kingdom.
  • Smith SA; Oncology Translational Medicine Unit, Early Clinical Development, AstraZeneca, Da Vinci Building, Melbourn Science Park, Melbourn, Royston SG8 6HB, United Kingdom.
  • Clack G; Translational Medicine Unit, Early Clinical Development, AstraZeneca, Alderley Park, Macclesfield SK10 4TG, United Kingdom.
  • Newham P; Drug Safety and Metabolism, AstraZeneca, Darwin Building, Cambridge Science Park, Milton Road, Cambridge CB4 0WG, United Kingdom.
Toxicol Appl Pharmacol ; 296: 10-8, 2016 Apr 01.
Article in En | MEDLINE | ID: mdl-26876616
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridazines / Vomiting / Receptors, Androgen / Models, Animal / Nausea Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans / Male Language: En Journal: Toxicol Appl Pharmacol Year: 2016 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridazines / Vomiting / Receptors, Androgen / Models, Animal / Nausea Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Limits: Animals / Female / Humans / Male Language: En Journal: Toxicol Appl Pharmacol Year: 2016 Type: Article