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Optimization of N'-(arylsulfonyl)pyrazoline-1-carboxamidines by exploiting a novel interaction site in the 5-HT6 antagonistic binding pocket.
van Loevezijn, Arnold; Venhorst, Jennifer; Iwema Bakker, Wouter I; Lange, Jos H M; de Looff, Wouter; Henzen, Remco; de Vries, Jelle; van de Woestijne, Rob P; den Hartog, Arnold P; Verhoog, Stefan; van der Neut, Martina A W; de Bruin, Natasja M W J; Kruse, Chris G.
Affiliation
  • van Loevezijn A; Abbott Healthcare Products B.V. (Formerly Solvay Pharmaceuticals B.V.), C.J. van Houtenlaan 36, 1381 CP Weesp, The Netherlands.
  • Venhorst J; Abbott Healthcare Products B.V. (Formerly Solvay Pharmaceuticals B.V.), C.J. van Houtenlaan 36, 1381 CP Weesp, The Netherlands. Electronic address: jennifer.mccormack@tno.nl.
  • Iwema Bakker WI; Abbott Healthcare Products B.V. (Formerly Solvay Pharmaceuticals B.V.), C.J. van Houtenlaan 36, 1381 CP Weesp, The Netherlands.
  • Lange JHM; Abbott Healthcare Products B.V. (Formerly Solvay Pharmaceuticals B.V.), C.J. van Houtenlaan 36, 1381 CP Weesp, The Netherlands.
  • de Looff W; Abbott Healthcare Products B.V. (Formerly Solvay Pharmaceuticals B.V.), C.J. van Houtenlaan 36, 1381 CP Weesp, The Netherlands.
  • Henzen R; Abbott Healthcare Products B.V. (Formerly Solvay Pharmaceuticals B.V.), C.J. van Houtenlaan 36, 1381 CP Weesp, The Netherlands.
  • de Vries J; Abbott Healthcare Products B.V. (Formerly Solvay Pharmaceuticals B.V.), C.J. van Houtenlaan 36, 1381 CP Weesp, The Netherlands.
  • van de Woestijne RP; Abbott Healthcare Products B.V. (Formerly Solvay Pharmaceuticals B.V.), C.J. van Houtenlaan 36, 1381 CP Weesp, The Netherlands.
  • den Hartog AP; Abbott Healthcare Products B.V. (Formerly Solvay Pharmaceuticals B.V.), C.J. van Houtenlaan 36, 1381 CP Weesp, The Netherlands.
  • Verhoog S; Abbott Healthcare Products B.V. (Formerly Solvay Pharmaceuticals B.V.), C.J. van Houtenlaan 36, 1381 CP Weesp, The Netherlands.
  • van der Neut MAW; Abbott Healthcare Products B.V. (Formerly Solvay Pharmaceuticals B.V.), C.J. van Houtenlaan 36, 1381 CP Weesp, The Netherlands.
  • de Bruin NMWJ; Abbott Healthcare Products B.V. (Formerly Solvay Pharmaceuticals B.V.), C.J. van Houtenlaan 36, 1381 CP Weesp, The Netherlands.
  • Kruse CG; Abbott Healthcare Products B.V. (Formerly Solvay Pharmaceuticals B.V.), C.J. van Houtenlaan 36, 1381 CP Weesp, The Netherlands.
Bioorg Med Chem Lett ; 26(6): 1605-1611, 2016 Mar 15.
Article in En | MEDLINE | ID: mdl-26876931
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Serotonin Antagonists / Sulfonamides / Receptors, Serotonin Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2016 Type: Article Affiliation country: Netherlands
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Serotonin Antagonists / Sulfonamides / Receptors, Serotonin Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2016 Type: Article Affiliation country: Netherlands