Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice.

Vicidomini, C; Ponzoni, L; Lim, D; Schmeisser, M J; Reim, D; Morello, N; Orellana, D; Tozzi, A; Durante, V; Scalmani, P; Mantegazza, M; Genazzani, A A; Giustetto, M; Sala, M; Calabresi, P; Boeckers, T M; Sala, C; Verpelli, C

Vicidomini, C; Ponzoni, L; Lim, D; Schmeisser, M J; Reim, D; Morello, N; Orellana, D; Tozzi, A; Durante, V; Scalmani, P; Mantegazza, M; Genazzani, A A; Giustetto, M; Sala, M; Calabresi, P; Boeckers, T M; Sala, C; Verpelli, C.

Affiliation

Vicidomini C; CNR Neuroscience Institute, Milan, Italy.
Ponzoni L; BIOMETRA University of Milan, Milan, Italy.
Lim D; Department of Pharmaceutical Sciences, Università degli Studi del Piemonte Orientale "Amedeo Avogadro", Novara, Italy.
Schmeisser MJ; Institute for Anatomy and Cell Biology, Ulm University, Ulm, Germany.
Reim D; Department of Neurology, Ulm University, Ulm, Germany.
Morello N; Institute for Anatomy and Cell Biology, Ulm University, Ulm, Germany.
Orellana D; Department of Neuroscience, University of Turin, Turin, Italy.
Tozzi A; CNR Neuroscience Institute, Milan, Italy.
Durante V; Department of Experimental Medicine, University of Perugia, Perugia, Italy.
Scalmani P; Department of Medicine, University of Perugia and Clinica Neurologica, Santa Maria della Misericordia Hospital, Perugia, Italy.
Mantegazza M; U.O. of Neurophysiopathology and Diagnostic Epileptology, Foundation Istituto di Ricerca e Cura a Carattere Scientifico Neurological Institute Carlo Besta, Milan, Italy.
Genazzani AA; Institute of Molecular and Cellular Pharmacology, Laboratory of Excellence Ion Channel Science and Therapeutics, CNRS UMR7275 and University of Nice-Sophia Antipolis, Valbonne, France.
Giustetto M; Department of Pharmaceutical Sciences, Università degli Studi del Piemonte Orientale "Amedeo Avogadro", Novara, Italy.
Sala M; Department of Neurology, Ulm University, Ulm, Germany.
Calabresi P; CNR Neuroscience Institute, Milan, Italy.
Boeckers TM; Department of Medicine, University of Perugia and Clinica Neurologica, Santa Maria della Misericordia Hospital, Perugia, Italy.
Sala C; Institute for Anatomy and Cell Biology, Ulm University, Ulm, Germany.
Verpelli C; CNR Neuroscience Institute, Milan, Italy.

Mol Psychiatry ; 22(5): 689-702, 2017 05.

Article in En | MEDLINE | ID: mdl-27021819

Subject(s)

Autism Spectrum Disorder/drug therapy; Autism Spectrum Disorder/genetics; Autism Spectrum Disorder/metabolism; Benzamides/pharmacology; Nerve Tissue Proteins/metabolism; Pyrazoles/pharmacology; Receptor, Metabotropic Glutamate 5/metabolism; Animals; Behavior, Animal/drug effects; Chromosome Deletion; Chromosome Disorders/genetics; Chromosome Disorders/metabolism; Chromosomes, Human, Pair 22/genetics; Chromosomes, Human, Pair 22/metabolism; Corpus Striatum/drug effects; Corpus Striatum/metabolism; Exons; Hippocampus/drug effects; Hippocampus/metabolism; Homer Scaffolding Proteins/metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Microfilament Proteins; Nerve Tissue Proteins/deficiency; Nerve Tissue Proteins/genetics; Neurons/drug effects; Neurons/metabolism; Post-Synaptic Density/metabolism; Signal Transduction; Synaptic Transmission

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Benzamides / Receptor, Metabotropic Glutamate 5 / Autism Spectrum Disorder / Nerve Tissue Proteins Limits: Animals Language: En Journal: Mol Psychiatry Journal subject: BIOLOGIA MOLECULAR / PSIQUIATRIA Year: 2017 Type: Article Affiliation country: Italy

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