PKCÎµ inhibits isolation and stemness of side population cells via the suppression of ABCB1 transporter and PI3K/Akt, MAPK/ERK signaling in renal cell carcinoma cell line 769P.

Huang, Bin; Fu, Shun Jun; Fan, Wen Zhe; Wang, Zhong Hua; Chen, Ze Bin; Guo, Sheng Jie; Chen, Jun Xing; Qiu, Shao Peng

Huang, Bin; Fu, Shun Jun; Fan, Wen Zhe; Wang, Zhong Hua; Chen, Ze Bin; Guo, Sheng Jie; Chen, Jun Xing; Qiu, Shao Peng.

Affiliation

Huang B; Department of Urology, the First Affiliated Hospital, Sun Yat-Sen University, No. 58 Zhong Shan 2nd Road, Guangzhou 510080, China.
Fu SJ; Organ Transplant Center, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Fan WZ; Department of Interventional Oncology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510080, China.
Wang ZH; Department of Intensive Care Unit, Guangdong Provincial Institute of Geriatric Medicine, Guangdong General Hospital & Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
Chen ZB; Department of Urology, the First Affiliated Hospital, Sun Yat-Sen University, No. 58 Zhong Shan 2nd Road, Guangzhou 510080, China.
Guo SJ; Department of Urology, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
Chen JX; Department of Urology, the First Affiliated Hospital, Sun Yat-Sen University, No. 58 Zhong Shan 2nd Road, Guangzhou 510080, China. Electronic address: junxingchen@hotmail.com.
Qiu SP; Department of Urology, the First Affiliated Hospital, Sun Yat-Sen University, No. 58 Zhong Shan 2nd Road, Guangzhou 510080, China. Electronic address: qiushpmed@163.com.

Cancer Lett ; 376(1): 148-54, 2016 06 28.

Article in En | MEDLINE | ID: mdl-27037060

Subject(s)

Carcinoma, Renal Cell/enzymology; Cell Separation/methods; Extracellular Signal-Regulated MAP Kinases/metabolism; Kidney Neoplasms/enzymology; Neoplastic Stem Cells/enzymology; Phosphatidylinositol 3-Kinase/metabolism; Protein Kinase C-epsilon/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Side-Population Cells/enzymology; ATP Binding Cassette Transporter, Subfamily B/metabolism; Animals; Carcinoma, Renal Cell/drug therapy; Carcinoma, Renal Cell/pathology; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Down-Regulation; Drug Resistance, Neoplasm; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Kidney Neoplasms/drug therapy; Kidney Neoplasms/pathology; Mice, Inbred NOD; Mice, SCID; Neoplasm Transplantation; Neoplastic Stem Cells/drug effects; Neoplastic Stem Cells/pathology; Phenotype; Phosphorylation; RNA Interference; STAT3 Transcription Factor/metabolism; Side-Population Cells/drug effects; Side-Population Cells/pathology; Signal Transduction; Time Factors; Transfection

Key words

ABCB1; Cancer stem cell; Protein kinase C epsilon; Renal cell carcinoma; Side population cells

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplastic Stem Cells / Carcinoma, Renal Cell / Cell Separation / Extracellular Signal-Regulated MAP Kinases / Protein Kinase C-epsilon / Proto-Oncogene Proteins c-akt / Side-Population Cells / Phosphatidylinositol 3-Kinase / Kidney Neoplasms Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Cancer Lett Year: 2016 Type: Article Affiliation country: China

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