HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants.

Macek Hrvat, Nikolina; Zunec, Suzana; Taylor, Palmer; Radic, Zoran; Kovarik, Zrinka

Macek Hrvat, Nikolina; Zunec, Suzana; Taylor, Palmer; Radic, Zoran; Kovarik, Zrinka.

Affiliation

Macek Hrvat N; Institute for Medical Research and Occupational Health, Zagreb, Croatia.
Zunec S; Institute for Medical Research and Occupational Health, Zagreb, Croatia.
Taylor P; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92093-0650, USA.
Radic Z; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92093-0650, USA.
Kovarik Z; Institute for Medical Research and Occupational Health, Zagreb, Croatia. Electronic address: zkovarik@imi.hr.

Chem Biol Interact ; 259(Pt B): 148-153, 2016 Nov 25.

Article in En | MEDLINE | ID: mdl-27083141

Subject(s)

Acetylcholinesterase/metabolism; Cholinesterase Inhibitors/metabolism; Cholinesterase Reactivators/metabolism; Organothiophosphorus Compounds/metabolism; Oximes/metabolism; Pyridinium Compounds/metabolism; Acetylcholinesterase/chemistry; Acetylcholinesterase/genetics; Animals; Binding Sites; Cholinesterase Inhibitors/chemistry; Cholinesterase Inhibitors/poisoning; Cholinesterase Reactivators/chemistry; Cholinesterase Reactivators/therapeutic use; Humans; Kinetics; Male; Mice; Mutagenesis, Site-Directed; Organophosphate Poisoning/drug therapy; Organophosphate Poisoning/mortality; Organophosphate Poisoning/veterinary; Organothiophosphorus Compounds/chemistry; Organothiophosphorus Compounds/poisoning; Oximes/chemistry; Oximes/therapeutic use; Pyridinium Compounds/chemistry; Pyridinium Compounds/therapeutic use; Recombinant Proteins/biosynthesis; Recombinant Proteins/chemistry; Survival Rate

Key words

2-PAM; Antidotes; Cholinesterase; Nerve agents; Organophosphates; Oximes; Reactivation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organothiophosphorus Compounds / Oximes / Acetylcholinesterase / Pyridinium Compounds / Cholinesterase Inhibitors / Cholinesterase Reactivators Limits: Animals / Humans / Male Language: En Journal: Chem Biol Interact Year: 2016 Type: Article Affiliation country: Croatia

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