MicroRNA-30c-1-3p is a silencer of the pregnane X receptor by targeting the 3'-untranslated region and alters the expression of its target gene cytochrome P450 3A4.

Vachirayonstien, Thaveechai; Yan, Bingfang

Vachirayonstien, Thaveechai; Yan, Bingfang.

Affiliation

Vachirayonstien T; Department of Biomedical and Pharmaceutical Sciences, Center for Integrated Drug Development, University of Rhode Island, Kingston, RI 02881, United States.
Yan B; Department of Biomedical and Pharmaceutical Sciences, Center for Integrated Drug Development, University of Rhode Island, Kingston, RI 02881, United States. Electronic address: byan@uri.edu.

Biochim Biophys Acta ; 1859(9): 1238-1244, 2016 09.

Article in En | MEDLINE | ID: mdl-27085140

Subject(s)

3' Untranslated Regions; Cytochrome P-450 CYP3A/genetics; Epithelial Cells/metabolism; Gene Expression Regulation; MicroRNAs/genetics; Receptors, Steroid/genetics; Base Sequence; Cell Line, Tumor; Cytochrome P-450 CYP3A/metabolism; Epithelial Cells/cytology; Genes, Reporter; HEK293 Cells; Hep G2 Cells; Humans; Luciferases/genetics; Luciferases/metabolism; MicroRNAs/metabolism; Plasmids/chemistry; Plasmids/metabolism; Pregnane X Receptor; Receptors, Steroid/metabolism; Signal Transduction; Transfection

Key words

Chemosensitivity; Drugdrug interaction; MicroRNA CYP3A4; Nuclear receptor; PXR

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Steroid / Gene Expression Regulation / 3' Untranslated Regions / MicroRNAs / Epithelial Cells / Cytochrome P-450 CYP3A Limits: Humans Language: En Journal: Biochim Biophys Acta Year: 2016 Type: Article Affiliation country: United States

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