Radical S-Adenosylmethionine Enzymes in Human Health and Disease.

Landgraf, Bradley J; McCarthy, Erin L; Booker, Squire J

Landgraf, Bradley J; McCarthy, Erin L; Booker, Squire J.

Affiliation

Landgraf BJ; Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802.
McCarthy EL; Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802.
Booker SJ; Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802.

Annu Rev Biochem ; 85: 485-514, 2016 Jun 02.

Article in En | MEDLINE | ID: mdl-27145839

Subject(s)

Diabetes Mellitus, Type 2/genetics; Heart Defects, Congenital/genetics; Metal Metabolism, Inborn Errors/genetics; Mutation; Neurodegenerative Diseases/genetics; S-Adenosylmethionine/metabolism; Carbon-Carbon Lyases; Diabetes Mellitus, Type 2/enzymology; Diabetes Mellitus, Type 2/pathology; Gene Expression; Heart Defects, Congenital/enzymology; Heart Defects, Congenital/pathology; Histone Acetyltransferases/genetics; Histone Acetyltransferases/metabolism; Humans; Intracellular Signaling Peptides and Proteins/genetics; Intracellular Signaling Peptides and Proteins/metabolism; Iron-Sulfur Proteins/genetics; Iron-Sulfur Proteins/metabolism; Metal Metabolism, Inborn Errors/enzymology; Metal Metabolism, Inborn Errors/pathology; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Neurodegenerative Diseases/enzymology; Neurodegenerative Diseases/pathology; Nuclear Proteins/genetics; Nuclear Proteins/metabolism; Oxidoreductases/genetics; Oxidoreductases/metabolism; Oxidoreductases Acting on CH-CH Group Donors; Proteins/genetics; Proteins/metabolism; Thioctic Acid/metabolism; tRNA Methyltransferases/genetics; tRNA Methyltransferases/metabolism

Key words

Elongator; S-adenosylmethionine; ironsulfur cluster; lipoic acid; molybdenum cofactor; radicals; tRNA modifications; viperin

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: S-Adenosylmethionine / Neurodegenerative Diseases / Diabetes Mellitus, Type 2 / Heart Defects, Congenital / Metal Metabolism, Inborn Errors / Mutation Limits: Humans Language: En Journal: Annu Rev Biochem Year: 2016 Type: Article

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