Chikusetsusaponin IVa Methyl Ester Isolated from the Roots of Achyranthes japonica Suppresses LPS-Induced iNOS, TNF-&#945;, IL-6, and IL-1ß Expression by NF-&#954;B and AP-1 Inactivation.

Lee, Hae-Jun; Shin, Ji-Sun; Lee, Woo-Seok; Shim, Heon-Yong; Park, Ji-Min; Jang, Dae-Sik; Lee, Kyung-Tae

Chikusetsusaponin IVa Methyl Ester Isolated from the Roots of Achyranthes japonica Suppresses LPS-Induced iNOS, TNF-α, IL-6, and IL-1ß Expression by NF-κB and AP-1 Inactivation.

Lee, Hae-Jun; Shin, Ji-Sun; Lee, Woo-Seok; Shim, Heon-Yong; Park, Ji-Min; Jang, Dae-Sik; Lee, Kyung-Tae.

Affiliation

Lee HJ; Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University.

Biol Pharm Bull ; 39(5): 657-64, 2016.

Article in En | MEDLINE | ID: mdl-27150139

Subject(s)

Achyranthes; Anti-Inflammatory Agents/pharmacology; Esters/pharmacology; Oleanolic Acid/analogs & derivatives; Saponins/pharmacology; Animals; Anti-Inflammatory Agents/isolation & purification; Cyclooxygenase 2/genetics; Cyclooxygenase 2/metabolism; Dinoprostone/metabolism; Esters/isolation & purification; Interleukin-1beta/genetics; Interleukin-1beta/metabolism; Interleukin-6/genetics; Interleukin-6/metabolism; Lipopolysaccharides; Mice; NF-kappa B/metabolism; Nitric Oxide Synthase Type II/genetics; Nitric Oxide Synthase Type II/metabolism; Oleanolic Acid/isolation & purification; Oleanolic Acid/pharmacology; Plant Roots/chemistry; RAW 264.7 Cells; Saponins/isolation & purification; Transcription Factor AP-1/metabolism; Tumor Necrosis Factor-alpha/genetics; Tumor Necrosis Factor-alpha/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oleanolic Acid / Saponins / Achyranthes / Esters / Anti-Inflammatory Agents Limits: Animals Language: En Journal: Biol Pharm Bull Journal subject: BIOQUIMICA / FARMACOLOGIA Year: 2016 Type: Article

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