Association of the C47T polymorphism in superoxide dismutase gene 2 with noise-induced hearing loss: a meta-analysis.
Braz J Otorhinolaryngol
; 83(1): 80-87, 2017.
Article
in En
| MEDLINE
| ID: mdl-27161188
ABSTRACT
INTRODUCTION:
Currently, there is limited information about the relationship between manganese superoxide dismutase (sod2) c47t polymorphism and susceptibility to noise-induced hearing loss (NIHL).OBJECTIVE:
The aim of this meta-analysis was to clarify the association between SOD2 C47T polymorphism and NIHL.METHODS:
A search in PubMed and Web of Science was performed to collect data. All full-text, English-written studies containing sufficient and complete case-and-control data about the relationship between SOD2 C47T polymorphism and NIHL were included. Three eligible studies, comprising 1094 subjects, were identified. pooled odds ratios (ORs) and 95% confidence intervals (CI) were calculated to evaluate the strength of the association between SOD2 C47T polymorphism and NIHL.RESULTS:
No significant association between C47T polymorphism and risk of NIHL was found with the following combinations T vs. C (OR=0.83; 95% CI=0.63-1.09); TT vs. CC (OR=0.49; 95% CI=0.22-1.09); CT vs. CC (OR=0.54; 95% CI=0.25-1.17); TT vs. CC+CT (OR=0.82; 95% CI=0.50-1.32); CC vs. TT+TC (OR=0.49; 95% CI=0.23-1.04). However, in subgroup analysis, a significant association was found for TT vs. CC+CT (OR=0.77; 95% CI=0.42-1.41) in the Chinese population.CONCLUSION:
The present meta-analysis suggests that SOD2 C47T polymorphism is significantly associated with increased risk of NIHL in the Chinese population. Further large and well-designed studies are needed to confirm this association.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polymorphism, Genetic
/
Superoxide Dismutase
/
Genetic Predisposition to Disease
/
Hearing Loss, Noise-Induced
Type of study:
Risk_factors_studies
/
Systematic_reviews
Limits:
Humans
Language:
En
Journal:
Braz J Otorhinolaryngol
Journal subject:
OTORRINOLARINGOLOGIA
Year:
2017
Type:
Article