ppGpp Binding to a Site at the RNAP-DksA Interface Accounts for Its Dramatic Effects on Transcription Initiation during the Stringent Response.

Ross, Wilma; Sanchez-Vazquez, Patricia; Chen, Albert Y; Lee, Jeong-Hyun; Burgos, Hector L; Gourse, Richard L

Ross, Wilma; Sanchez-Vazquez, Patricia; Chen, Albert Y; Lee, Jeong-Hyun; Burgos, Hector L; Gourse, Richard L.

Affiliation

Ross W; Department of Bacteriology, University of Wisconsin-Madison, 1550 Linden Drive, Madison, WI 53706, USA.
Sanchez-Vazquez P; Department of Bacteriology, University of Wisconsin-Madison, 1550 Linden Drive, Madison, WI 53706, USA.
Chen AY; Department of Bacteriology, University of Wisconsin-Madison, 1550 Linden Drive, Madison, WI 53706, USA.
Lee JH; Department of Bacteriology, University of Wisconsin-Madison, 1550 Linden Drive, Madison, WI 53706, USA.
Burgos HL; Department of Bacteriology, University of Wisconsin-Madison, 1550 Linden Drive, Madison, WI 53706, USA.
Gourse RL; Department of Bacteriology, University of Wisconsin-Madison, 1550 Linden Drive, Madison, WI 53706, USA. Electronic address: rgourse@bact.wisc.edu.

Mol Cell ; 62(6): 811-823, 2016 06 16.

Article in En | MEDLINE | ID: mdl-27237053

Subject(s)

DNA-Directed RNA Polymerases/metabolism; Escherichia coli Proteins/metabolism; Escherichia coli/metabolism; Guanosine Tetraphosphate/metabolism; Stress, Physiological; Transcription Initiation, Genetic; Amino Acid Sequence; Binding Sites; Conserved Sequence; DNA-Directed RNA Polymerases/chemistry; DNA-Directed RNA Polymerases/genetics; Escherichia coli/genetics; Escherichia coli Proteins/chemistry; Escherichia coli Proteins/genetics; Evolution, Molecular; Gene Expression Regulation, Bacterial; Models, Molecular; Protein Binding; Protein Conformation; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stress, Physiological / DNA-Directed RNA Polymerases / Escherichia coli Proteins / Escherichia coli / Transcription Initiation, Genetic / Guanosine Tetraphosphate Type of study: Prognostic_studies Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2016 Type: Article Affiliation country: United States

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