A supported liquid extraction LC-MS/MS method for determination of concentrations of GDC-0425, a small molecule Checkpoint kinase 1 inhibitor, in human plasma.

Ding, Xiao; Chen, Yuan; Sahasranaman, Srikumar; Shi, Yifan; McKnight, Janine; Dean, Brian

Ding, Xiao; Chen, Yuan; Sahasranaman, Srikumar; Shi, Yifan; McKnight, Janine; Dean, Brian.

Affiliation

Ding X; Genentech, Drug Metabolism and Pharmacokinetics, 1 DNA Way, South San Francisco, CA, USA.
Chen Y; Genentech, Drug Metabolism and Pharmacokinetics, 1 DNA Way, South San Francisco, CA, USA.
Sahasranaman S; Genentech, Small Molecule Clinical Pharmacology, 1 DNA Way, South San Francisco, CA, USA.
Shi Y; Covance Laboratories, 3301 Kinsman Blvd., Madison, WI, USA.
McKnight J; Covance Laboratories, 3301 Kinsman Blvd., Madison, WI, USA.
Dean B; Genentech, Drug Metabolism and Pharmacokinetics, 1 DNA Way, South San Francisco, CA, USA.

Biomed Chromatogr ; 30(12): 1984-1991, 2016 Dec.

Article in En | MEDLINE | ID: mdl-27245274

Subject(s)

Checkpoint Kinase 1/antagonists & inhibitors; Chromatography, Liquid/methods; Heterocyclic Compounds, 3-Ring/blood; Piperidines/blood; Protein Kinase Inhibitors/blood; Tandem Mass Spectrometry/methods; Hemolysis; Heterocyclic Compounds, 3-Ring/pharmacokinetics; Humans; Limit of Detection; Piperidines/pharmacokinetics; Reference Standards; Reproducibility of Results

Key words

GDC-0425; LC-MS/MS; checkpoint kinase 1 (ChK1); human plasma; supported liquid extraction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperidines / Chromatography, Liquid / Protein Kinase Inhibitors / Tandem Mass Spectrometry / Checkpoint Kinase 1 / Heterocyclic Compounds, 3-Ring Limits: Humans Language: En Journal: Biomed Chromatogr Year: 2016 Type: Article Affiliation country: United States

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