Origins of Allostery and Evolvability in Proteins: A Case Study.

Raman, Arjun S; White, K Ian; Ranganathan, Rama

Raman, Arjun S; White, K Ian; Ranganathan, Rama.

Affiliation

Raman AS; Green Center for Systems Biology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA.
White KI; Green Center for Systems Biology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA.
Ranganathan R; Green Center for Systems Biology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA; Departments of Biophysics and Pharmacology, University of Texas Southwestern Medical Center, 6001 Forest Park Road, Dallas, TX 75390, USA. Electronic address: rama.ranganathan@utsouthwestern.edu.

Cell ; 166(2): 468-480, 2016 Jul 14.

Article in En | MEDLINE | ID: mdl-27321669

Subject(s)

Evolution, Molecular; Intracellular Signaling Peptides and Proteins/chemistry; Intracellular Signaling Peptides and Proteins/genetics; Membrane Proteins/chemistry; Membrane Proteins/genetics; Allosteric Regulation; Animals; Disks Large Homolog 4 Protein; Intracellular Signaling Peptides and Proteins/metabolism; Membrane Proteins/metabolism; Models, Molecular; Mutation; Protein Domains; Protein Engineering; Rats

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Evolution, Molecular / Intracellular Signaling Peptides and Proteins / Membrane Proteins Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cell Year: 2016 Type: Article Affiliation country: United States

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