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Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study.
Prins, Bram P; Abbasi, Ali; Wong, Anson; Vaez, Ahmad; Nolte, Ilja; Franceschini, Nora; Stuart, Philip E; Guterriez Achury, Javier; Mistry, Vanisha; Bradfield, Jonathan P; Valdes, Ana M; Bras, Jose; Shatunov, Aleksey; Lu, Chen; Han, Buhm; Raychaudhuri, Soumya; Bevan, Steve; Mayes, Maureen D; Tsoi, Lam C; Evangelou, Evangelos; Nair, Rajan P; Grant, Struan F A; Polychronakos, Constantin; Radstake, Timothy R D; van Heel, David A; Dunstan, Melanie L; Wood, Nicholas W; Al-Chalabi, Ammar; Dehghan, Abbas; Hakonarson, Hakon; Markus, Hugh S; Elder, James T; Knight, Jo; Arking, Dan E; Spector, Timothy D; Koeleman, Bobby P C; van Duijn, Cornelia M; Martin, Javier; Morris, Andrew P; Weersma, Rinse K; Wijmenga, Cisca; Munroe, Patricia B; Perry, John R B; Pouget, Jennie G; Jamshidi, Yalda; Snieder, Harold; Alizadeh, Behrooz Z.
Affiliation
  • Prins BP; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Abbasi A; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, United Kingdom.
  • Wong A; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Vaez A; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom.
  • Nolte I; Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Franceschini N; Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada.
  • Stuart PE; Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
  • Guterriez Achury J; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Mistry V; School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Bradfield JP; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Valdes AM; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, United States of America.
  • Bras J; Department of Dermatology, Veterans Affairs Hospital, University of Michigan, Ann Arbor, Michigan, United States of America.
  • Shatunov A; Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
  • Evangelou E; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America.
  • Nair RP; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America.
  • Grant SF; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America.
  • Polychronakos C; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
  • Radstake TR; Division of Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.
  • van Heel DA; Partners HealthCare Center for Personalized Genetic Medicine, Boston, Massachusetts, United States of America.
  • Dunstan ML; Faculty of Medical and Human Sciences, University of Manchester, Manchester, United Kingdom.
  • Wood NW; Neurology Unit, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
  • Al-Chalabi A; Division of Rheumatology and Clinical Immunogenetics, University of Texas Health Science Center at Houston, Houston, Texas, United States of America.
  • Dehghan A; Department of Dermatology, Veterans Affairs Hospital, University of Michigan, Ann Arbor, Michigan, United States of America.
  • Hakonarson H; Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America.
  • Markus HS; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
  • Elder JT; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.
  • Knight J; Department of Dermatology, Veterans Affairs Hospital, University of Michigan, Ann Arbor, Michigan, United States of America.
  • Arking DE; Center for Applied Genomics, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, United States of America.
  • Spector TD; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America.
  • Koeleman BP; Endocrine Genetics Research Institute, McGill University Health Center, Montreal, Quebec, Canada.
  • van Duijn CM; Department of Rheumatology & Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands.
  • Martin J; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
  • Morris AP; Institute of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United Kingdom.
  • Weersma RK; Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom.
  • Wijmenga C; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
  • Munroe PB; Complex Disease Genetics, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America.
  • Perry JR; Department of Epidemiology, Erasmus University Rotterdam, University Medical Centre Rotterdam, Rotterdam, the Netherlands.
  • Pouget JG; Center for Applied Genomics, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, United States of America.
  • Jamshidi Y; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America.
  • Snieder H; Neurology Unit, Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.
  • Alizadeh BZ; Department of Dermatology, Veterans Affairs Hospital, University of Michigan, Ann Arbor, Michigan, United States of America.
PLoS Med ; 13(6): e1001976, 2016 06.
Article in En | MEDLINE | ID: mdl-27327646
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: C-Reactive Protein / Genome-Wide Association Study / Mendelian Randomization Analysis / Heart Diseases / Immune System Diseases / Mental Disorders / Metabolic Diseases Type of study: Clinical_trials / Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: PLoS Med Journal subject: MEDICINA Year: 2016 Type: Article Affiliation country: Netherlands
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: C-Reactive Protein / Genome-Wide Association Study / Mendelian Randomization Analysis / Heart Diseases / Immune System Diseases / Mental Disorders / Metabolic Diseases Type of study: Clinical_trials / Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: PLoS Med Journal subject: MEDICINA Year: 2016 Type: Article Affiliation country: Netherlands