The effects of verapamil on the pharmacokinetics of curculigoside in rats.

Wang, Kaiyou; Zhao, Jingming; Lang, Jixiao

Wang, Kaiyou; Zhao, Jingming; Lang, Jixiao.

Affiliation

Wang K; a Department of Orthopaedics , Qingdao Hiser Medical Group , Qingdao , Shandong , China.
Zhao J; a Department of Orthopaedics , Qingdao Hiser Medical Group , Qingdao , Shandong , China.
Lang J; a Department of Orthopaedics , Qingdao Hiser Medical Group , Qingdao , Shandong , China.

Pharm Biol ; 54(12): 3001-3008, 2016 Dec.

Article in En | MEDLINE | ID: mdl-27328778

Subject(s)

Benzoates/pharmacokinetics; Glucosides/pharmacokinetics; Verapamil/pharmacokinetics; Administration, Oral; Animals; Benzoates/administration & dosage; Caco-2 Cells; Chromatography, Liquid/methods; Drug Interactions/physiology; Glucosides/administration & dosage; Humans; Male; Mass Spectrometry/methods; Microsomes, Liver/drug effects; Microsomes, Liver/metabolism; Rats; Rats, Sprague-Dawley; Verapamil/administration & dosage

Key words

CYP450; Caco-2 cells; P-gp; oral absolute bioavailability; verapamil

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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Benzoates / Verapamil / Glucosides Limits: Animals / Humans / Male Language: En Journal: Pharm Biol Year: 2016 Type: Article Affiliation country: China

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