HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption.

Scheid, Johannes F; Horwitz, Joshua A; Bar-On, Yotam; Kreider, Edward F; Lu, Ching-Lan; Lorenzi, Julio C C; Feldmann, Anna; Braunschweig, Malte; Nogueira, Lilian; Oliveira, Thiago; Shimeliovich, Irina; Patel, Roshni; Burke, Leah; Cohen, Yehuda Z; Hadrigan, Sonya; Settler, Allison; Witmer-Pack, Maggi; West, Anthony P; Juelg, Boris; Keler, Tibor; Hawthorne, Thomas; Zingman, Barry; Gulick, Roy M; Pfeifer, Nico; Learn, Gerald H; Seaman, Michael S; Bjorkman, Pamela J; Klein, Florian; Schlesinger, Sarah J; Walker, Bruce D; Hahn, Beatrice H; Nussenzweig, Michel C; Caskey, Marina

Scheid, Johannes F; Horwitz, Joshua A; Bar-On, Yotam; Kreider, Edward F; Lu, Ching-Lan; Lorenzi, Julio C C; Feldmann, Anna; Braunschweig, Malte; Nogueira, Lilian; Oliveira, Thiago; Shimeliovich, Irina; Patel, Roshni; Burke, Leah; Cohen, Yehuda Z; Hadrigan, Sonya; Settler, Allison; Witmer-Pack, Maggi; West, Anthony P; Juelg, Boris; Keler, Tibor; Hawthorne, Thomas; Zingman, Barry; Gulick, Roy M; Pfeifer, Nico; Learn, Gerald H; Seaman, Michael S; Bjorkman, Pamela J; Klein, Florian; Schlesinger, Sarah J; Walker, Bruce D; Hahn, Beatrice H; Nussenzweig, Michel C; Caskey, Marina.

Nature ; 535(7613): 556-60, 2016 07 28.

Article in En | MEDLINE | ID: mdl-27338952

Subject(s)

Anti-HIV Agents/administration & dosage; Antibodies, Neutralizing/immunology; HIV Antibodies/immunology; HIV Infections/drug therapy; HIV Infections/virology; HIV-1/growth & development; HIV-1/immunology; Adolescent; Adult; Aged; Anti-HIV Agents/pharmacology; Anti-HIV Agents/therapeutic use; Antibodies, Monoclonal, Humanized; Antibodies, Neutralizing/administration & dosage; Antibodies, Neutralizing/therapeutic use; Binding Sites/drug effects; Binding Sites/immunology; Broadly Neutralizing Antibodies; CD4 Antigens/metabolism; Disease Reservoirs/virology; Drug Administration Schedule; Female; HIV Antibodies/administration & dosage; HIV Antibodies/therapeutic use; HIV Envelope Protein gp160/antagonists & inhibitors; HIV Envelope Protein gp160/chemistry; HIV Envelope Protein gp160/immunology; HIV Envelope Protein gp160/metabolism; HIV Infections/immunology; HIV-1/drug effects; Historically Controlled Study; Humans; Male; Middle Aged; Proviruses/drug effects; Proviruses/growth & development; Proviruses/immunology; Time Factors; Tissue Distribution; Viral Load/drug effects; Viral Load/immunology; Young Adult

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV Antibodies / HIV Infections / HIV-1 / Anti-HIV Agents / Antibodies, Neutralizing Type of study: Clinical_trials Language: En Journal: Nature Year: 2016 Type: Article

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