Allosteric coupling from G protein to the agonist-binding pocket in GPCRs.

DeVree, Brian T; Mahoney, Jacob P; Vélez-Ruiz, Gisselle A; Rasmussen, Soren G F; Kuszak, Adam J; Edwald, Elin; Fung, Juan-Jose; Manglik, Aashish; Masureel, Matthieu; Du, Yang; Matt, Rachel A; Pardon, Els; Steyaert, Jan; Kobilka, Brian K; Sunahara, Roger K

DeVree, Brian T; Mahoney, Jacob P; Vélez-Ruiz, Gisselle A; Rasmussen, Soren G F; Kuszak, Adam J; Edwald, Elin; Fung, Juan-Jose; Manglik, Aashish; Masureel, Matthieu; Du, Yang; Matt, Rachel A; Pardon, Els; Steyaert, Jan; Kobilka, Brian K; Sunahara, Roger K.

Nature ; 535(7610): 182-6, 2016 07 07.

Article in En | MEDLINE | ID: mdl-27362234

Subject(s)

Allosteric Site; GTP-Binding Protein alpha Subunits, Gs/metabolism; Receptors, Adrenergic, beta-2/chemistry; Receptors, Adrenergic, beta-2/metabolism; Adrenergic beta-2 Receptor Agonists/metabolism; Adrenergic beta-2 Receptor Antagonists/metabolism; Allosteric Regulation/drug effects; Allosteric Site/drug effects; GTP-Binding Protein alpha Subunits, Gs/pharmacology; Guanine/metabolism; Guanine/pharmacology; Humans; Kinetics; Ligands; Models, Molecular; Protein Binding/drug effects; Protein Conformation/drug effects; Receptors, Adrenergic, beta-2/immunology; Single-Chain Antibodies/immunology; Single-Chain Antibodies/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Adrenergic, beta-2 / GTP-Binding Protein alpha Subunits, Gs / Allosteric Site Type of study: Prognostic_studies Limits: Humans Language: En Journal: Nature Year: 2016 Type: Article

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