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Effect of Fluoxetine on Neurogenesis in Hippocampal Dentate Gyrus after Global Transient Cerebral Ischemia in Rats.
Khodanovich, M Yu; Kisel', A A; Chernysheva, G A; Smol'yakova, V I; Savchenko, R R; Plotnikov, M B.
Affiliation
  • Khodanovich MY; Department of Neurobiology, Research Institute of Biology and Biophysics, Tomsk State University, Tomsk, Russia. khodanovich@mail.tsu.ru.
  • Kisel' AA; Department of Neurobiology, Research Institute of Biology and Biophysics, Tomsk State University, Tomsk, Russia.
  • Chernysheva GA; Department of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
  • Smol'yakova VI; Department of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
  • Savchenko RR; Department of Neurobiology, Research Institute of Biology and Biophysics, Tomsk State University, Tomsk, Russia.
  • Plotnikov MB; Department of Circulation Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
Bull Exp Biol Med ; 161(3): 351-4, 2016 Jul.
Article in En | MEDLINE | ID: mdl-27496030
ABSTRACT
Changes in cerebral neurogenesis provoked by ischemia and the effect of fluoxetine on this process were studied using a three-vessel occlusion model of global transient cerebral ischemia. The global transient cerebral ischemia was modeled on male Wistar rats by transient occlusion of three major vessels originating from the aortic arch and supplying the brain (brachiocephalic trunk, left subclavian artery, and left common carotid artery). The cells expressing doublecortin (DCX, a marker of young neurons) were counted in the hippocampal dentate gyrus on day 31 after ischemia modeling. It was found that ischemia inhibited neurogenesis in the dentate gyrus in comparison with sham-operated controls (p<0.05), while fluoxetine (20 mg/kg/day) injected over 10 days after surgery restored neurogenesis to the control level (p<0.001).
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ischemic Attack, Transient / Fluoxetine / Dentate Gyrus / Neurogenesis Limits: Animals Language: En Journal: Bull Exp Biol Med Year: 2016 Type: Article Affiliation country: RUSSIA
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ischemic Attack, Transient / Fluoxetine / Dentate Gyrus / Neurogenesis Limits: Animals Language: En Journal: Bull Exp Biol Med Year: 2016 Type: Article Affiliation country: RUSSIA