Shelterin Telomere Protection Protein 1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirtuin 1 Deacetylase in Chronic Obstructive Pulmonary Disease.

Ahmad, Tanveer; Sundar, Isaac K; Tormos, Ana M; Lerner, Chad A; Gerloff, Janice; Yao, Hongwei; Rahman, Irfan

Ahmad, Tanveer; Sundar, Isaac K; Tormos, Ana M; Lerner, Chad A; Gerloff, Janice; Yao, Hongwei; Rahman, Irfan.

Affiliation

Ahmad T; Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York.
Sundar IK; Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York.
Tormos AM; Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York.
Lerner CA; Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York.
Gerloff J; Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York.
Yao H; Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York.
Rahman I; Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York.

Am J Respir Cell Mol Biol ; 56(1): 38-49, 2017 01.

Article in En | MEDLINE | ID: mdl-27559927

Subject(s)

Cellular Senescence; DNA-Binding Proteins/metabolism; Pulmonary Disease, Chronic Obstructive/metabolism; Pulmonary Disease, Chronic Obstructive/pathology; Shelterin Complex/metabolism; Sirtuin 1/metabolism; Telomere-Binding Proteins/metabolism; Telomere/metabolism; Acetylation; Animals; Cells, Cultured; DNA Damage; Epithelial Cells/metabolism; Epithelial Cells/pathology; Fibroblasts/metabolism; Fibroblasts/pathology; Humans; Lung/metabolism; Lung/pathology; Mice; Mice, Inbred C57BL; Protein Binding; Pulmonary Emphysema/metabolism; Pulmonary Emphysema/pathology; Smoking/adverse effects

Key words

Sirtuin1; cellular senescence; emphysema; shelterin complex; telomeric DNA damage

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Telomere / Cellular Senescence / Pulmonary Disease, Chronic Obstructive / Telomere-Binding Proteins / DNA-Binding Proteins / Sirtuin 1 / Shelterin Complex Type of study: Etiology_studies Limits: Animals / Humans Language: En Journal: Am J Respir Cell Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2017 Type: Article

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