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Discovery of novel 5-hydroxy-4-pyridone-3-carboxy acids as potent inhibitors of influenza Cap-dependent endonuclease.
Miyagawa, Masayoshi; Akiyama, Toshiyuki; Mikamiyama-Iwata, Minako; Hattori, Kazunari; Kurihara, Naoko; Taoda, Yoshiyuki; Takahashi-Kageyama, Chika; Kurose, Noriyuki; Mikamiyama, Hidenori; Suzuki, Naoyuki; Takaya, Kenji; Tomita, Kenji; Matsuo, Kenji; Morimoto, Kenji; Yoshida, Ryu; Shishido, Takao; Yoshinaga, Tomokazu; Sato, Akihiko; Kawai, Makoto.
Affiliation
  • Miyagawa M; Medicinal Chemistry Research Laboratory, Shionogi & Co., Ltd, 1-1, Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: masayoshi.miyagawa@shionogi.co.jp.
  • Akiyama T; Medicinal Chemistry Research Laboratory, Shionogi & Co., Ltd, 1-1, Futabacho, 3-chome, Toyonaka 561-0825, Japan.
  • Mikamiyama-Iwata M; Medicinal Chemistry Research Laboratory, Shionogi & Co., Ltd, 1-1, Futabacho, 3-chome, Toyonaka 561-0825, Japan.
  • Hattori K; Medicinal Chemistry Research Laboratory, Shionogi & Co., Ltd, 1-1, Futabacho, 3-chome, Toyonaka 561-0825, Japan.
  • Kurihara N; Medicinal Chemistry Research Laboratory, Shionogi & Co., Ltd, 1-1, Futabacho, 3-chome, Toyonaka 561-0825, Japan.
  • Taoda Y; Medicinal Chemistry Research Laboratory, Shionogi & Co., Ltd, 1-1, Futabacho, 3-chome, Toyonaka 561-0825, Japan.
  • Takahashi-Kageyama C; Medicinal Chemistry Research Laboratory, Shionogi & Co., Ltd, 1-1, Futabacho, 3-chome, Toyonaka 561-0825, Japan.
  • Kurose N; Medicinal Chemistry Research Laboratory, Shionogi & Co., Ltd, 1-1, Futabacho, 3-chome, Toyonaka 561-0825, Japan.
  • Mikamiyama H; Medicinal Chemistry Research Laboratory, Shionogi & Co., Ltd, 1-1, Futabacho, 3-chome, Toyonaka 561-0825, Japan.
  • Suzuki N; Medicinal Chemistry Research Laboratory, Shionogi & Co., Ltd, 1-1, Futabacho, 3-chome, Toyonaka 561-0825, Japan.
  • Takaya K; Medicinal Chemistry Research Laboratory, Shionogi & Co., Ltd, 1-1, Futabacho, 3-chome, Toyonaka 561-0825, Japan.
  • Tomita K; Medicinal Chemistry Research Laboratory, Shionogi & Co., Ltd, 1-1, Futabacho, 3-chome, Toyonaka 561-0825, Japan.
  • Matsuo K; Medicinal Chemistry Research Laboratory, Shionogi & Co., Ltd, 1-1, Futabacho, 3-chome, Toyonaka 561-0825, Japan.
  • Morimoto K; Research Laboratory for Development, Shionogi & Co., Ltd, 1-1, Futabacho, 3-chome, Toyonaka 561-0825, Japan.
  • Yoshida R; Drug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd, 1-1, Futabacho, 3-chome, Toyonaka 561-0825, Japan.
  • Shishido T; Drug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd, 1-1, Futabacho, 3-chome, Toyonaka 561-0825, Japan.
  • Yoshinaga T; Drug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd, 1-1, Futabacho, 3-chome, Toyonaka 561-0825, Japan.
  • Sato A; Drug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd, 1-1, Futabacho, 3-chome, Toyonaka 561-0825, Japan.
  • Kawai M; Medicinal Chemistry Research Laboratory, Shionogi & Co., Ltd, 1-1, Futabacho, 3-chome, Toyonaka 561-0825, Japan.
Bioorg Med Chem Lett ; 26(19): 4739-4742, 2016 10 01.
Article in En | MEDLINE | ID: mdl-27568084
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Orthomyxoviridae / Pyridones / Endonucleases / Enzyme Inhibitors / Drug Discovery Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2016 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Orthomyxoviridae / Pyridones / Endonucleases / Enzyme Inhibitors / Drug Discovery Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2016 Type: Article