Population Pharmacokinetics and Dosing Regimen Optimization of Meropenem in Cerebrospinal Fluid and Plasma in Patients with Meningitis after Neurosurgery.

Lu, Cheng; Zhang, Yuyi; Chen, Mingyu; Zhong, Ping; Chen, Yuancheng; Yu, Jicheng; Wu, Xiaojie; Wu, Jufang; Zhang, Jing

Lu, Cheng; Zhang, Yuyi; Chen, Mingyu; Zhong, Ping; Chen, Yuancheng; Yu, Jicheng; Wu, Xiaojie; Wu, Jufang; Zhang, Jing.

Affiliation

Lu C; Institute of Antibiotics, Huashan Hospital Affiliated to Fudan University, Shanghai, China.
Zhang Y; Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, China.
Chen M; Institute of Antibiotics, Huashan Hospital Affiliated to Fudan University, Shanghai, China.
Zhong P; Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, China.
Chen Y; Department of Neurosurgery, Huashan Hospital Affiliated to Fudan University, Shanghai, China.
Yu J; Department of Neurosurgery, Huashan Hospital Affiliated to Fudan University, Shanghai, China.
Wu X; Institute of Antibiotics, Huashan Hospital Affiliated to Fudan University, Shanghai, China.
Wu J; Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, China.
Zhang J; Institute of Antibiotics, Huashan Hospital Affiliated to Fudan University, Shanghai, China.

Antimicrob Agents Chemother ; 60(11): 6619-6625, 2016 11.

Article in En | MEDLINE | ID: mdl-27572392

Subject(s)

Anti-Bacterial Agents/pharmacokinetics; Gram-Negative Bacteria/drug effects; Meningitis, Bacterial/drug therapy; Neurosurgery; Thienamycins/pharmacokinetics; Adult; Aged; Anti-Bacterial Agents/cerebrospinal fluid; Brain Injuries, Traumatic/pathology; Brain Injuries, Traumatic/surgery; Brain Neoplasms/pathology; Brain Neoplasms/surgery; Drug Administration Schedule; Female; Gram-Negative Bacteria/growth & development; Humans; Infusions, Intravenous; Male; Meningitis, Bacterial/cerebrospinal fluid; Meningitis, Bacterial/etiology; Meningitis, Bacterial/microbiology; Meropenem; Microbial Sensitivity Tests; Middle Aged; Monte Carlo Method; Postoperative Complications; Prospective Studies; Thienamycins/cerebrospinal fluid

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thienamycins / Meningitis, Bacterial / Gram-Negative Bacteria / Anti-Bacterial Agents / Neurosurgery Type of study: Etiology_studies / Health_economic_evaluation / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Antimicrob Agents Chemother Year: 2016 Type: Article Affiliation country: China

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