Prefrontal Cortex-Mediated Impairments in a Genetic Model of NMDA Receptor Hypofunction Are Reversed by the Novel M<sub>1</sub> PAM VU6004256.

Grannan, Michael D; Mielnik, Catharine A; Moran, Sean P; Gould, Robert W; Ball, Jacob; Lu, Zhuoyan; Bubser, Michael; Ramsey, Amy J; Abe, Masahito; Cho, Hyekyung P; Nance, Kellie D; Blobaum, Anna L; Niswender, Colleen M; Conn, P Jeffrey; Lindsley, Craig W; Jones, Carrie K

Prefrontal Cortex-Mediated Impairments in a Genetic Model of NMDA Receptor Hypofunction Are Reversed by the Novel M₁ PAM VU6004256.

Grannan, Michael D; Mielnik, Catharine A; Moran, Sean P; Gould, Robert W; Ball, Jacob; Lu, Zhuoyan; Bubser, Michael; Ramsey, Amy J; Abe, Masahito; Cho, Hyekyung P; Nance, Kellie D; Blobaum, Anna L; Niswender, Colleen M; Conn, P Jeffrey; Lindsley, Craig W; Jones, Carrie K.

Affiliation

Grannan MD; Department of Pharmacology, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States.
Mielnik CA; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States.
Moran SP; Department of Pharmacology and Toxicology, University of Toronto , Toronto, Ontario M5S 1A8, Canada.
Gould RW; Department of Pharmacology, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States.
Ball J; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States.
Lu Z; Department of Pharmacology, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States.
Bubser M; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States.
Ramsey AJ; Department of Pharmacology, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States.
Abe M; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States.
Cho HP; Department of Pharmacology, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States.
Nance KD; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States.
Blobaum AL; Department of Pharmacology, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States.
Niswender CM; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States.
Conn PJ; Department of Pharmacology and Toxicology, University of Toronto , Toronto, Ontario M5S 1A8, Canada.
Lindsley CW; Department of Pharmacology, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States.
Jones CK; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center , Nashville, Tennessee 37232, United States.

ACS Chem Neurosci ; 7(12): 1706-1716, 2016 12 21.

Article in En | MEDLINE | ID: mdl-27617634

Subject(s)

Cholinergic Agents/pharmacology; Heterocyclic Compounds, 4 or More Rings/pharmacology; Nerve Tissue Proteins/deficiency; Nootropic Agents/pharmacology; Prefrontal Cortex/drug effects; Prefrontal Cortex/metabolism; Receptors, N-Methyl-D-Aspartate/deficiency; Action Potentials/drug effects; Action Potentials/physiology; Animals; Cholinergic Agents/pharmacokinetics; Cognition Disorders/drug therapy; Cognition Disorders/metabolism; Conditioning, Psychological/drug effects; Conditioning, Psychological/physiology; Disease Models, Animal; Drug Evaluation, Preclinical; Fear/drug effects; Fear/physiology; Gene Knockdown Techniques; Heterocyclic Compounds, 4 or More Rings/pharmacokinetics; Long-Term Synaptic Depression/drug effects; Long-Term Synaptic Depression/physiology; Male; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity/drug effects; Motor Activity/physiology; Nerve Tissue Proteins/genetics; Nootropic Agents/pharmacokinetics; Pyramidal Cells/drug effects; Pyramidal Cells/metabolism; Receptors, N-Methyl-D-Aspartate/genetics; Recognition, Psychology/drug effects; Recognition, Psychology/physiology; Tissue Culture Techniques

Key words

M1 muscarinic; NR1 KD; VU6004256; antipsychotic; cognitive enhancement; positive allosteric modulator

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prefrontal Cortex / Receptors, N-Methyl-D-Aspartate / Nootropic Agents / Cholinergic Agents / Heterocyclic Compounds, 4 or More Rings / Nerve Tissue Proteins Type of study: Prognostic_studies Limits: Animals Language: En Journal: ACS Chem Neurosci Year: 2016 Type: Article Affiliation country: United States

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